45例慢性淋巴组织增生性疾病临床资料分析  

Clinical analysis of 45 cases with chronic lymphoproliferative diseases

作　　者：王伟良[1] 裴雷[1] 惠玉荣[1] 邢宝利[1] 许晓冬[1] 郑天林[1] 顾惜春[1] 

机构地区：[1]卫生部北京医院血液科,北京100730

出　　处：《临床血液学杂志》2006年第5期269-271,共3页Journal of Clinical Hematology

摘　　要：目的:研究慢性淋巴组织增生性疾病的诊断和鉴别诊断方法。方法:对45例慢性淋巴组织增生性疾病(CLPD)的临床资料,包括临床征象、细胞形态学、免疫学标记等进行分析。结果:45例CLPD患者中慢性淋巴细胞白血病35例,幼淋细胞白血病8例,带有绒毛样淋巴细胞原发性淋巴瘤及毛细胞白血病各1例。35例CLL均为B细胞,其中CD5和CD19均阳性,而CD10均阴性,临床首发表现以血淋巴细胞增高为多见。8例PLL,6例为B细胞型,骨髓中以幼淋细胞为主,免疫表现CD5均阴性,CD19均阳性。结论:依据临床征象、细胞形态学和免疫表型分析,可诊断CLPD的各个类型。Objective：To explore the diagnosis and differentiate diagnosis of chronic lymphoproliferative disea ses. Method：Clinical data of 45 cases with chronic lymphoproliferative diseases was analyzed, including clinical features, marrow cell morphology, immunophenotype, etc. Result：45patients consisted of 35 with CLL, 8 with PLL, 1 with HCL, 1 with ATLL. All 35 CLL cases had B-cell marker： CD19＋, CD5＋, CD10- , initial sign in most patients was lymphocytosis in routine blood test. 6 PLL expressed B-cell immunological marks： CD19＋, CD5-. Pre-lymphocyted amounts increase in marrow. 2 PLL had Tcell marks. Conclusion：Diagnosis and differentiate diagnosis of CI.PD should be synthetical analysis according to clinical features, cell morphology, immunological marker, molecular biology and genetics.

关 键 词：淋巴组织增生性疾病 慢性 临床征象 细胞形态学 免疫学标记 

分 类 号：R551.21[医药卫生—血液循环系统疾病]