八氯二丙醚暴露工人微核及DNA损伤程度  

Micronuclei and DNA damage in peripheral lymphocyte of workers occupationally exposed to octachlorodipropyl ether

作　　者：唐萌[1] 叶明宪[2] 袁震华 周天文 王波[4] 刘岚[2] 熊丽林[1] 曾垂焕[1] 李倩[5] 王晓娜[1] 

机构地区：[1]东南大学公共卫生学院,南京210009 [2]江苏省疾病预防控制中心 [3]江苏省兴化市病预防控制中心 [4]复旦大学 [5]南京航空航天大学

出　　处：《中国公共卫生》2006年第9期1082-1083,共2页Chinese Journal of Public Health

基　　金：江苏省预防医学基金资助项目(Y200421)

摘　　要：目的了解八氯二丙醚暴露可能对工人造成的健康危害。方法对八氯二丙醚(S2)生产工人进行流行病学调查,并采集外周血进行微核(MN)和单细胞凝胶电泳试验(SCGE),了解S2可能对工人健康的损伤。结果八氯二丙醚接触者外周血微核发生率较对照组无明显增加(P>0.05),DNA表现出不同程度的损伤(P<0.01)。结论目前S2生产车间有害气体的暴露水平对工人外周血DNA有一定的损伤作用。Objective To understand the effects of octachlorodipropyl ether on the health of workers. Methods To make an epidemiological survey of the workers occupationally exposed to octachlorodipropyl ether（S2 ）by micronucleus test and single cell gel electrophoresis assay（SCGE）. Results There was no significant increase in frequency of micronuclei of thoseexposed to octachlorodipropyl ether（Sz）as compared with the control group. DNA damage was more severe in the group exposed to octachlorodipropyl ether（S2）. Conclusion Occupational exposure to S2 producing process may cause DNA damages in peripheral Lymphocyte of workers.

关 键 词：八氯二丙醚 微核 DNA损伤 流行病学 

分 类 号：R139.3[医药卫生—劳动卫生]