混配农药对家兔诱发电位及脑组织ATP酶的影响  

Effects of mixed pesticides on somatosensory evoked potential and activities of ATPase of brains in rabbits

作　　者：林立[1] 张璟[1] 曾晓立[1] 张强[1] 

机构地区：[1]济宁医学院职业卫生与环境医学重点实验室,山东济宁272013

出　　处：《中国公共卫生》2006年第9期1117-1118,共2页Chinese Journal of Public Health

摘　　要：目的研究混配农药对家兔中枢神经系统功能的影响及其机制。方法将家兔随机分为混配农药染毒A组(丙溴磷与氰戊菊酯混配染毒组)、混配农药染毒B组(丙溴磷与灭多威混配染毒组)和1个对照组,每组6只。3个染毒组分别给予3种染毒剂量进行染毒,于染毒前后进行家兔体感染诱发电位(SEP)及染毒后大脑组织三磷酸腺苷(ATP)酶活力的测定。结果与对照组比较,2个混配农药染毒组的高剂量组染毒后SEP的N1、P1、N2波潜伏时均显著延长(P<0.01),2个混配农药染毒组的高中剂量组染毒后的Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶的活力明显下降(P<0.05,P<0.01)。结论一定剂量的混配农药可导致家兔中枢神经系统功能的的改变,这种改变可能与大脑组织中Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活力的下降有关。Objective To explore the effects of mixed pesticides on the Somatosensory evoked potential（SEP）and the activities of ATPase of brains in rabbits. Methods Rabbits were divided into 2 mixed pesticide exposure groups and 1 control group. A group were poisoned by profenofos and fenvalerate, and B group were poisoned by profenofos and methomyl. The SEP were measured in each group before and after poisoning by mixed pesticide, and the activites of Na^＋- K^＋ - ATPase and Ca^2 ＋ - Mg^2 ＋ - ATPase of the brain was measured in each group after poisoning by mixed pesticide. Results Compared with the control group, the potential periods of N1, P2, N2 in high - dose exposure group in A group and B group delayed significantly after poisoning by mixed pesticide（ P 〈 0.01）. Compared with the control group, the activities of Na^＋ - K^＋ - ATPase and Ca^2＋ - Mg^2＋ - ATPase decreased significantly in high- dose exposure groups and middle-dose groups in A group and Bgroup after poisonging by mixed pesticide（P 〈 0.05, P 〈 0.01）. Conclusion The mixed pesticides can harm the functions of central nervous system, which must be related to the decrease of the activities of Na^＋ K^＋ - ATPase and Ca^2＋ - Mg^2＋ - ATPase in brain.

关 键 词：混配农药 体感诱发电位 NA^+-K^+-ATP酶 Ca^2n—Mg^2+-ATP酶 

分 类 号：R114[医药卫生—卫生毒理学]