肠易激综合征乙状结肠移行性运动与胃肠肽胆囊收缩素、胃动素的相关性研究  

The relationship between sigmoid colon propagating motility and cholecystokinin and motilin in patients with irritable bowel syndrome.

作　　者：张志雄[1] 郑琴芳[1] 梁荣新[1] 蔡联英[1] 梁列新[1] 张法灿[1] 

机构地区：[1]广西壮族自治区人民医院消化内科,广西南宁530021

出　　处：《中国实用内科杂志：临床前沿版》2006年第9期1427-1429,共3页

基　　金：广西留学回国人员基金(桂科回9920013)

摘　　要：目的研究肠易激综合征(IBS)患者乙状结肠移行性运动与胃肠肽胆囊收缩素(CCK)、胃动素(MTL)的关系,探讨CCK、MTL对IBS患者乙状结肠动力的调节作用。方法对2004年3月至2005年2月,在广西壮族自治区人民医院消化内科住院,符合罗马Ⅱ诊断标准的腹泻型(D-IBS)和便秘型(C-IBS)IBS患者各20例及年龄、性别匹配的健康志愿者组15名(男7名、女8名),分别采用毛细管液体灌注测压法记录空腹状态下乙状结肠移行性高幅突发波的波幅及占记录时间百分比;同时采用放射免疫法测定所有研究对象血浆和乙状结肠黏膜CCK、MTL的含量。结果D-IBS组乙状结肠移行性高幅突发波的波幅和持续时间显著高于C-IBS组和健康组(P<0.05),D-IBS组血浆MTL、CCK浓度显著高于C-IBS组和健康组(P<0.01),黏膜MTL显著高于C-IBS组和健康组(P<0.01)。IBS患者乙状结肠移行高幅突发波的波幅和持续时间与血浆或黏膜CCK、MTL分别呈正相关(P<0.05)。结论IBS患者乙状结肠移行性运动可能受血浆CCK、黏膜和血浆MTL浓度相关的正性调节作用。Objective To investigate the relationship between the sigmoid colon propagating contractions and the gut hormones cholecystokinin （CCK） and motilin （MTL） in the patients with irritable bowel syndrome （IBS） , and to reveal the gut hormones＇ modulation to the sigmoid colon motility. Methods Twenty diarrea - predominent IBS patients （ D - IBS）, and sex/age matched 20 constipation - predominent IBS patients （ C - IBS） and 15 healthy volunteers were enrolled in the study. From June 2005 to Mar. 2006, the high amplitude propagating waves and loger time of the sigmoid colon was measured by means of a liquid - perfused capillary tube connected to a computer. Meanwhile, the concentrations of CCK, MTL of blood plasma and sigmoid colon mucosa were tested by means of immunoassay technology. Results The D - IBS group had higher amplitude of the sigmoid colon propagating waves and their time percentage than that of the C - IBS group and the control group （P 〈 0. 05 ）. The plasmal concentrations of CCK and MTL in the D - IBS group were higher than those in C - IBS group and the control group （ P 〈 0. 01 ） , and so did the mucosal concentrations of MTL （P 〈0. 01 ）. The amplitude of the propagating waves and their time percentages were positively correlated with plasmal or mucosal CCK and MTL concentrations （ P 〈 0.05 ）. Conclusion The sigmoid colon propagating motility in IBS may positively be modulated by plasmal CCK and MTL and mucosal MTL concentrations.

关 键 词：肠易激综合征 乙状结肠动力 胆囊收缩素 胃动素 

分 类 号：R5[医药卫生—内科学]