支气管哮喘患儿血清SIL-2R和T淋巴细胞亚群的相关性探讨  

Study on the relationship between serum soluble IL-2 receptor(SIL-2R) concentration and distribution pattern of peripheral blood T-cell subsets in patients with bronchial asthma

作　　者：刘恒[1] 

机构地区：[1]江苏省连云港市第一人民医院儿科,222002

出　　处：《淮海医药》2006年第5期376-377,共2页Journal of Huaihai Medicine

摘　　要：目的探讨血清可溶性白细胞介素-2受体(S IL-2R)和T淋巴细胞亚群在支气管哮喘患儿中的作用。方法应用双抗体夹心EL ISA法和单克隆抗体法对32例支气管哮喘患儿进行了血清S IL-2R和T淋巴细胞亚群的测定,并以35名正常人作对照。结果支气管哮喘患儿在治疗前血清S IL-2R水平非常显著地高于正常人组(P<0.01),至恢复期虽然S IL-2R水平有所下降,但与正常人组比较差异仍有显著性(P<0.01)。S IL-2R水平与T淋巴细胞亚群中CD 8细胞比值密切相关。结论检测支气管哮喘患儿血清S IL-2R和T淋巴细胞亚群水平可以作为患者病情变化、预后判断的重要检测指标。Objective To investigate the serum SIL-2R concentration and T-cell subsets distribution pattern in patients with bronchial asthma. Methods Serum SIL-2R levels （with ELISA） and peripheral blood T-cell subsets distribution pattern （with monoelonal antibody technique）were determined in 32 patients with bronchial asthma and 35 controls. Results Before treatment serum SIL-2R levels were significantly higher than those in controls（P〈0.0] ）. The serum levels dropped during convalescence btlt still remained significantly higher than those in controls （P〈0. 01）. Serum SIL-2R levels were positively correlated with CD4/CD8 ratio. Conclusion Data from this study were compatible with the theory that the diseases mechanism of bronchial asthma might be related to a systemic delayed type of super-Hyper-Sensitive celhllar immune response.

关 键 词：哮喘 受体 白细胞介素-2 T淋巴细胞亚群 

分 类 号：R725.622.5[医药卫生—儿科]