D_1多巴胺受体与原发性高血压  

D_1 Dopamine Receptor and Essential Hypertension

作　　者：李震[1] 曾春雨[1] 杨成明[1] 

机构地区：[1]第三军医大学大坪医院心内科心血管病研究室

出　　处：《心血管病学进展》2006年第5期572-575,共4页Advances in Cardiovascular Diseases

摘　　要：多巴胺可通过对肾脏水钠重吸收的调节作用,进而发挥对血压调控的影响,多巴胺功能障碍在原发性高血压发生过程中发挥重要的作用。在多巴胺受体的5个亚型中,D1受体的作用尤其引人注目。在体内钠负荷过载的情况下,刺激肾脏D1受体可调节超过50%的钠排量。原发性高血压状态下D1受体功能障碍,其发生的原因与D1受体/G蛋白效应物复合体失偶联有关,而其失偶联的机制归因于G蛋白激酶4变异体存在所引起的G蛋白激酶活性增高。Dopamine receptor plays an important role in essential hypertension by regulating renal sodium and water excretion. Dt dopamine receptor is the most important of the five dopamine receptor subtypes. Stimulation of D1 receptor can control more than 50% of sodium excretion from the body in the sodium-replete states. D1 receptor function is impaired in essential hypertension states, which is due to the uncoupling of D1 receptor and G protein-effector. G protein related kinase 4 mutants increase G protein related kinase activity, which, in turn, leads to the uncoupling of D1 receptor and G protein-effectors.

关 键 词：多巴胺 D1多巴胺受体 尿钠排泄 近端小管 G蛋白激酶 

分 类 号：R544.1[医药卫生—心血管疾病]