远隔器官缺血预处理心脏保护作用的研究进展  

Advances in Research into the Cardioprotective Effects of Remote Ischemic Preconditioning

作　　者：李春梅[1] 张兴华[1] 

机构地区：[1]山东大学山东省立医院心内科,山东济南250021

出　　处：《心血管病学进展》2006年第5期631-634,共4页Advances in Cardiovascular Diseases

摘　　要：心肌缺血预处理现象的发现,为心肌缺血再灌注损伤的预防开拓了一个新的研究领域。近年来,随着预处理研究的不断深入,其方法学也有一些新的进展。研究发现,心外组织如肾脏、小肠及骨骼肌短暂缺血不仅能减轻局部组织的再灌注损伤,对远隔的心脏也有保护作用,并将这种现象称为远隔预处理。现就远隔器官缺血预处理对心脏的保护作用及其机制作一简要综述。The discovery of the phenomenon of ischemic preconditioning has created a new field of research into the prevention and inhibition of myocardial iscllemia-reperfusion injury. There have been recent advances in the methodology of ischemic preconditioning. Studies have shown that extracardiac isehemia,sueh as isehemia of the kidney, ischemia of the intestine and isehemia of the skeletal muscle, may not only lessen reperfusion injuries, but also protect the heart from remote reperfusion injuries. This phenomenon has been termed remote preeonditioning. This article summarizes the current information regarding the eardioprotection of remote preconditioning and the possible mechanisms involved.

关 键 词：远隔预处理 缺血预处理 心脏保护 

分 类 号：R541[医药卫生—心血管疾病]