补体C3、C4、备解素及补体调节蛋白CD55、CD59与颈动脉内膜中层厚度的关系研究  

A Study of the Relationship Between Complement C3, C4, Properdin, Complement Regueatory Proteins CD55, CD59 and Carotid Artery Intima-Media Thickness

作　　者：尚东亚[1] 马苏美[2] 刘永铭[1] 马西文[1] 何津春[3] 

机构地区：[1]兰州大学第一医院老年病科,甘肃省兰州市730000 [2]兰州大学第一医院超声诊断科,甘肃省兰州市730000 [3]兰州大学第一医院检验科,甘肃省兰州市730000

出　　处：《中国循环杂志》2006年第4期279-281,共3页Chinese Circulation Journal

基　　金：本课题受国家"十五"重大科技专项子项目(2002BA711A08-21)资助

摘　　要：目的:探讨补体及补体调节蛋白与颈动脉内膜中层厚度(IMT)的关系。方法:选高脂血症患者57例(高脂血症组),正常对照20人(正常对照组),测定补体C3、C4、备解素(Pf)水平、补体凋节蛋白CD55、CD59的表达及颈动脉IMT,分析其关系。结果:与正常对照组比较,高脂血症组补体C3、C4及备解素、颈动脉IMI、明显升高,补体调节蛋白CD55阳性淋巴细胞平均荧光强度减低;IMT与年龄、收缩压、腰臀比值、高敏C反应蛋白正相关,与补体调节蛋白CD55阳性淋巴细胞平均荧光强度负相关,与补体C3、C4、备解素及补体调节蛋白CD59不相关。结论:颈动脉IMT增厚与补体调节蛋白CD55表达降低相关,而与补体C3、C4、备解素、补体调节蛋白CD59无直接关系。Objective：To investigate the association between complement components, complement regulatory proteins and carotid artery intima-media thickness（IMT） in patients with hyperlipidemia. Methods：Fifty seven patients with hyperlipidemia were recruited in this study and 20 healthy volunteers served as controls. Serum C3, CA, properdin,the expressions of CD55, CD59 on leucocytes, and IMT were examined, and the relationship between them was analyzed. Results ： Compared with healthy controls, serum levels of C3, C4, properdin in hyperlipidemic patients were significantly increased（ 1.47 ±0.40 g/L vs 1.21 ±0. 26 g/L,0. 37 ±0. 14 g/L vs 0. 29 ±0. 09 g/L,0. 39 ±0. 11 g/L vs 0. 35 ±0. 06 g/L, P = 0. 000, 0. 000, 0. 004）, while the mean fluorescence intensity （MFI） of CD55-positive lymphocytes was markedly decreased （2. 05±0. 31 vs 2. 33 ±0. 38, P =0. 000）. Carotid artery IMT was increased in hyperlipidemic group, which was positively correlated with age, systolic pressure, waist-hip ratio, hsCRP and, negatively with MFI of CD55-positive lymphocytes, but not with complement C3, C4, and properdin and CD59. Conclusion：The increased IMT might be related with down-regulation of complement regulatory protein CD55 expression, but has no direct association with complement C3, C4, properdin and CD59.

关 键 词：补体 补体调节蛋白 颈动脉内膜中层厚度 

分 类 号：R541[医药卫生—心血管疾病]