碳包铁纳米粒子作为磁性靶向药物载体的物理性能研究  

PHYSICAL PERFORMANCE OF CARBON-COATED IRON NANOPARTICLES AS DRUG CARRIER SYSTEM WITH MAGNETIC TARGETING

作　　者：张海燕[1] 郑云[2] 周纯[1] 劳向明[2] 何艳阳[1] 李锦清[2] 陈易明[1] 曾国勋[1] 

机构地区：[1]广东工业大学材料与能源学院,广州510006 [2]中山大学肿瘤防治中心,广州510060

出　　处：《生物物理学报》2006年第4期310-316,共7页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(50372013);"十五"国家科技攻关计划项目(2003BA310A24);高等学校博士学科点专项科研基金项目(20050562002);广东省科技计划项目(2004B10301008)~~

摘　　要：一种全新的磁靶向纳米药物载体——用直流碳弧法制备的碳包铁纳米粒子,它具有独特的纳米结构,在石墨碳层中完全包裹进铁纳米颗粒,实现在纳米碳包围中的纳米磁性粒子分散状态,其中的纳米碳具有大的比表面积和较高的化疗药物吸附量,达到每毫克吸附160μg的表阿霉素。铁纳米粒子磁场强,靶向效果好,有较佳的磁靶向发热效应,在动物病灶局部放置0.1g碳包铁纳米粒子将能使发热温度平均升到52℃;而将碳包铁纳米粒子均匀与猪肝混合也有明显的产热效果:含量0.4%碳包铁纳米粒子的一组猪肝能将温度升到42℃,而含量0.6%碳包铁纳米粒子的一组猪肝能将温度升到48℃。X射线衍射表明借助于碳的包裹,碳包铁纳米粒子有好的抗氧化性和稳定性。碳包铁纳米粒子有可能作为一种全新的磁性靶向药物载体用于癌症治疗。Carbon-coated iron nanoparticles a new nano drug carrier with magnetic targeting were produced by carbon arc method. It presents an especial appearance of iron nanoparticles in inner core and nano-carbon shell outside. The nano-carbon shell outside has larger surface area, higher adsorption on medicament and can absorb Epirubicin of 160μg/mg measured by means of an optical spectrometer. The iron nanoparticles in inner core have good magnetism and targeting heating effect. The temperature can go up to 52 ~C in the case that 0.1 g carrier （carbon-coated iron nanoparticles） is injected in a local point of pig＇s liver, while the temperature can go up to 42℃ in the case that pig＇s liver uniformly containing carrier of 0.4 wt.% and 45℃ in the case that pig＇s liver uniformly containing carrier of 0.6 wt.%. Carbon-coated iron nanoparticles also has good antioxidation and stability by an X-rays diffraction （XRD） structural analysis. These carbon-coated iron nanoparticles can be used as a new kind of magnetic drug carrier for cancer therapy.

关 键 词：碳包铁纳米粒子 磁性靶向药物载体 物理性能 

分 类 号：Q68[生物学—生物物理学]