451例难治性肺结核耐药分析  

作　　者：陶五昌[1] 高建彬[1] 郭磊[1] 李伟[1] 卫风谦 范素莲 

机构地区：[1]新乡医学院结核病研究所,453100

出　　处：《综合临床医学》1996年第6期300-301,共2页

摘　　要：为探讨难治性肺结核耐药情况,找出其耐药的特点,自1990年;对在我院门诊及住院治疗的复治涂阳病人2425例进行痰培养和8种常用抗结核药物的耐药性测定,从中筛选出451例难治性肺结核进行耐药分析.1 对象及方法1.1 451例难治性肺结核选例标准1.1.1 经化疗痰菌培养持续或间断阳性超过2年,耐药2种(包括2种)以上,X线显示单侧或双侧广泛性纤维干酪增殖性病变,并伴有纤维空洞或厚壁洞者.1.1.2 年龄、性别不限,无心、肝、肾疾患,无糖尿病、尘肺、精神病等合并症者.1.2 结核菌培养及耐药性测定采用改良罗氏培养基,In order to look into the causes of the drug resistance of anti-tuberculotic drugs and find the drug resistance characteristics, 451 cases with refractory pulmonary tuberculosis were studied. The results indicated that the drug tolerance of Rifampicin and Rimifon in low and high concentration was confirmed in 375(83.1%) and 333(73.8%), 403(89.4%) and 375( 79. 2%) ,respectively. The drug resistanceof kinds of anti-tuberculotic drugs was found in some of the patients. The relationships between the formation of refractory pulmonary tuberculosis and tuberculous treatment and production of drug resistance were discussed in this report.

关 键 词：肺结核 耐药性 

分 类 号：R521.05[医药卫生—内科学]