高同型半胱氨酸和慢性肾脏疾病死亡原因的相关性研究  

Relationship Between Homocysteine and Mortality in Chronic Kidney Disease

作　　者：薛浩 

出　　处：《中国分子心脏病学杂志》2006年第2期99-99,共1页Molecular Cardiology of China

摘　　要：研究背景：血浆高半胱氨酸的水平和3、4期慢性肾脏疾病的预后关系目前还尚未被研究。方法和结果：肾脏疾病饮食调节研究入选了840名患者，测量血浆高半胱氨酸基线水平，患者的生存状况和死亡原因从国家死亡索引中获得。血浆高半胱氨酸分为3个水平（〈14．7，14．7to19．5，〉or=19．6mmol／L）和其作为连续变量（10mmol／L）来评价血浆高半胱氨酸和全因死亡及心血管疾病原因死亡的相关性。患者的平均年龄52±12岁，肾小球滤过率（33±12／1．72）m^2，60％为男性，85％为白人，平均随访10年，195（24％）名患者死于其他原因，118（15％）名死亡于心血管疾病，在血浆高半胱氨酸最高组，肾小球滤过率较低而蛋白尿水平较高。Background The relationship between total homocysteine （tHcy） and outcomes has not been investigated in patients with chronic kidney disease stages 3 to 4. Methods and Results The Modification of Diet in Renal Disease Study was a randomized, controlled trial of 840 patients. Serum tHcy was measured in frozen samples collected at baseline （ n = 804）. Survival status and cause of death were obtained from the National Death Index. To evaluate its association with all-cause and cardiovascular disease （CVD） mortality, tHcy was evaluated both as tertiles （ 〈 14.7, 14.7 to 19.5, 19.6 μmol/L） and as a continuous variable （per 10μmol/L）. Participants had a mean age of 52 ± 12 years and glomerular filtration rate （GFR） of 33 ± 12 mL/min per 1.73 m^2; 60% were male, and 85% were white. During a median follow-up of 10 years, 195 （24%） died from any cause, and 118 （15%） from CVD. The level of GFR was lower and proteinuria higher in the highest tHcy tertile.

关 键 词：慢性肾脏疾病 死亡原因 高同型半胱氨酸 相关性 血浆高半胱氨酸 肾小球滤过率 心血管疾病 平均年龄 

分 类 号：R692[医药卫生—泌尿科学]