固体稳定性和辅料相容性的研究进展  

Advances of stability and excipient compatibility of solid drugs

作　　者：王弘[1] 王东晓[1] 王波[1] 

机构地区：[1]中国人民解放军总医院药品保障中心,北京100853

出　　处：《中国新药杂志》2006年第16期1337-1341,共5页Chinese Journal of New Drugs

基　　金：国家自然科学基金(30472056)

摘　　要：固体稳定性和辅料相容性对新产品研制起着重要作用,现综述固体药物的稳定性和辅料相容性的研究进展,通过对固体稳定性的动力学模型以及影响固体稳定性的化学和物理因素的分析,提出提高固体稳定性、辅料相容性研究的多种方法,为新剂型开发提供有用信息。Studies of stability and excipient compatibility of solid drug have been of great concern in the innovative medical agents. Methodologies to improve the stability and excipient compatibility of solid drugs include the investigations of dynamic model and physicochemical settings of stability test. This paper highlights advances in the researches of stability and excipient compatibility of solid drugs, facilitating further exploration of new pharmaceuticals.

关 键 词：固体稳定性 固体动力学处理 辅料相容性 稳定性因素 辅料筛选 

分 类 号：R944.2[医药卫生—药剂学]