刺五加总黄酮对小鼠红细胞膜流动性的影响  

Effect of total flavonoids of acanthopanax senticosus on erythrocyte membrane fluidity in mice

作　　者：温筱煦[1] 程丽静[1] 刘蔚[1] 冯端浩[1] 孙玲[1] 

机构地区：[1]解放军总医院第二附属医院药剂科,北京市100091

出　　处：《中国基层医药》2006年第8期1256-1257,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察刺五加提取物中总黄酮的含量及其对红细胞膜流动性的影响。方法采用分光光度法测定刺五加总黄酮的含量,采用荧光偏振法测定红细胞膜流动性和微粘度。结果刺五加提取物与刺五加注射液的总黄酮含量相近,两组溶液均可增加红细胞膜流动性,降低微粘度,其中刺五加注射液的作用更为显著。结论刺五加总黄酮可以增加红细胞膜流动性,从而降低血液粘度,改善血液流变学指标。Objective To observe contents and effect of total flavonoids of acanthopanax senticosus extract on erythrocyte membrane fluidity. Methods The contents of total flavonoids of acanthopanax senticosus were determined by spectrophotometry,and erythrocyte membrane fluidity and microviscosity were measured by fluorescence polarization technique. Results The total flavonoids contents of acanthopanax senticosus extract and injection were alike. Both of them increased erythrocyte membrane fluidity and lowered microviscosity, and the effect of acanthopanax senticosus injection was more significant. Conclusion Total flavonoids of acanthopanax senticosus can increase erythrocyte membrane fluidity,so that blood viscosity is lowered and hemorheology factors are improved.

关 键 词：刺五加 总黄酮 红细胞膜流动性 微粘度 

分 类 号：R285.5[医药卫生—中药学]