抽动障碍各亚型事件相关电位N400的比较  

Comparison of N400 in Children with Different Subtypes of Tic Disorder

作　　者：欧利民[1] 胡莲清[1] 郑璇[1] 吴育彬[1] 李森美[1] 庄伟端[1] 林丽丽[1] 肖颖秀[1] 

机构地区：[1]汕头大学医学院第一附属医院神经内科,广东汕头515041

出　　处：《汕头大学医学院学报》2006年第3期162-164,共3页Journal of Shantou University Medical College

基　　金：广东省卫生厅资助项目资助(A2003500)

摘　　要：目的:比较抽动障碍(TD)各亚型患者事件相关电位N400的变化,并探讨其意义。方法:用MEB-9104K诱发电位检测系统测定病例组(11例Tourette氏障碍、17例慢性运动TD、7例一过性TD)及对照组(20例正常儿童)N400,并比较其潜伏期及波幅。结果:病例组Tourette氏障碍潜伏期(648.04±150.19)ms,波幅(28.82±19.09)μV;慢性运动TD潜伏期(724.89±215.23)ms,波幅(23.90±9.97)μV;一过性TD潜伏期(760.67±233.20)ms,波幅(27.85±12.72)μV;对照组潜伏期(485.75±85.76)ms,波幅(22.35±19.76)μV。病例组各亚型N400潜伏期较对照组长(P<0.001),波幅比无统计学意义(P>0.05)。各亚型之间N400潜伏期及波幅比均无统计学意义(P>0.05)。结论:TD患者存在认知功能缺陷,各亚型之间认知功能无差别。Objective： To study the differences of event-related potentials N400 and its significances in children with different subtypes of tie disorder（TD）. Methods： N400 of ease group（ 11 eases with Tourette＇s disorder, 17 eases with chronic motor TD, 7 eases with transient TD）and control group（20 healthy children）was determinated. Results： N400 latency of Tourette＇s disorder was（648.04 ± 150.19）ms and the amplitude was （28.82 ± 19.09）μV, the latency of chronic motor TD was （724.89 ± 215.23）ms and the amplitude was（23.90± 9.97）μV, the latency of transient TD was （760.67 ± 233.20）ms and the amplitude was（27.85 ~ 12.72）μV. The latency of control group was（485.75 ± 85.76） ms and the amplitude was（22.35 ± 19.76）μV. N400 latency of ease group was signitieanfly longer than that of control group（ P 〈 0.001）. There were no obvious differences of amplitude and latency between subtypes（ P 〉 0.05）. Conclusion： Children with TD show impaired cognition. There is no difference of cognitive function between subtypes of TD.

关 键 词：抽动性运动障碍 事件相关电位 N400 认知 

分 类 号：R338.8[医药卫生—人体生理学]