123例初治涂阳肺结核患者抗结核抗体阳性率分析  

Analysis on the Positive Rate of Anti-tuberculosis Antibody of 123 New Smear Positive Pulmonary Tuberculosis Cases

作　　者：黄景彬[1] 严舒俊[1] 谢胜华[1] 李永财[1] 

机构地区：[1]广东佛山市顺德区慢性病防治中心,广东佛山528300

出　　处：《医学信息（西安上半月）》2006年第9期1599-1602,共4页Medical Information

摘　　要：目的 探讨血清抗结核抗体诊断肺结核的敏感性以及肺结核患者病情及其它机体因素对抗结核抗体阳性率的影响。方法 采用酶联免疫吸附法检测痰结核菌培养为人型或牛型结核分枝杆菌的初治涂阳肺结核患者共123例的血清抗结核抗体，分析抗结核抗体阳性率并将检验结果与患者性别、年龄、病变范围、空洞情况、病程、合并症、痰菌量、菌型等的关系进行统计学分析。结果 初治涂阳肺结核患者血清抗结核抗体总阳性率为46．3％；30岁或以下、30至60岁及60岁或以上患者抗结核抗体阳性率分别为34、8％、59，3％和37．0％（P〈0．05）；伴空洞形成和无空洞患者抗结核抗体阳性率分别为56．6％和38，6％（P〈0．05）；而其它各因素对抗结核抗体阳性率均无显著性影响（P〉0．05）。结论 检测患者血清抗结核抗体诊断肺结核的敏感性较低。肺结核患者病情和机体因素对抗结核抗体阳性率的影响主要表现在30-60岁年龄组患者阳性率高于其他年龄组、有空洞形成者高于无空洞者。Objective To evaluate the diagnostic sensitivity of anti - tuberculosis antibody for pulmonary tuberculosis and investigate the effect of the severity and other individual factors on anti - tuberculosis antibody of pulmonary tuberculosis patients. Methods Enzyme linked immunosorbent assay method was used to test the serum anti - tuberculosis antibody of each of the 123 new smear positive pulmonary tuberculosis patients whose results of bacteria culture of sputum showed mycobacterium tuberculosis or mycobacterium tuberculosis var bovis, the positive rate of anti - tuberculosis antibody and the relationship between the results and the severity or other individual factors of the patients were analyzed. Results It showed that the total positive rate of anti - tuberculosis antibody was 46.3%. The positive rate was 34.8% , 59.3% and 37.0% in the patients at the age of ≤ 30, 30 - 60, and ≥60 respectively （ P 〈 0.05 ）, and 56.6% , 38.6% in the patients with and without cavity respectively （P 〈 0.05 ）. The effects of the other factors on anti -tuberculosis antibody were not significant （ P 〉 0.05 ）. Conclusions The sensitivity of anti - tuberculosis antibody for pulmonary tuberculosis is quite low. The positive rate of anti - tuberculosis antibody of the patients at the age of 30 - 60 is higher than the patients of other ages, and the positive rate of the patients with cavity is higher than the patients without cavity.

关 键 词：初治涂阳肺结核 抗结核抗体 阳性率 相关因素 酶联免疫吸附法 

分 类 号：R521[医药卫生—内科学]