激活素A及抑制素A与子痫前期的相关性  

RELATIONSHIP BETWEEN SERUM INHIBIN A AND ACTIVIN A CONCENTRATIONS AND PREECLAMPSIA

作　　者：王琳[1] 刘群英[2] 叶元华[3] 吕秀翠[2] 

机构地区：[1]青岛大学医学院第二附属医院产科,山东青岛266042 [2]青岛市第八人民医院产科 [3]青岛大学医学院附属医院产科

出　　处：《齐鲁医学杂志》2006年第6期471-473,共3页Medical Journal of Qilu

摘　　要：目的探讨子痫前期病人血清抑制素A和激活素A的水平变化及其与病情的关系。方法采用酶联免疫分析法(ELISA),检测了40例子痫前期病人(子痫前期组,包括轻度20例,重度20例)及40例正常妊娠妇女(正常妊娠组)的血清抑制素A和激活素A水平。结果子痫前期组病人血清抑制素A、激活素A水平均高于正常妊娠组,差异有统计学意义(t=69.93、30.12,P<0.01);其中重度子痫前期病人血清抑制素A、激活素A水平高于轻度子痫前期病人,差异有统计学意义(t=43.88、18.84,P<0.01)。两组病人血清抑制素A与激活素A水平呈正相关(r=0.59、0.52,P<0.01);子痫前期组病人血清抑制素A、激活素A水平与24 h尿蛋白含量呈显著正相关(r=0.76、0.56,P<0.01)。重度子痫前期伴胎儿生长受限(FGR)与不伴FGR病人血清抑制素A、激活素A水平差异无统计学意义(P>0.05)。结论子痫前期病人血清抑制素A、激活素A水平较正常妊娠妇女显著升高,且与子痫前期病情进展关系密切。Objective To investigate whether inhibin A and activin A serum levels are altered in women with preeclampsia. Methods Serum samples of 40 women with preeclampsia （study group, 20 patients with mild preeclampsia and another 20 with severe preeclampsia） and 40 normal pregnant women （control group） were assayed for inhibin A and activin A by specific enzyme-linked immunosorbent assay （ELISA）. Results The serum concentrations of inhibin A and activin A were significantly higher in the study group than in the control group （t=69.93, 30.12; P〈0.01）. Compared with those of the mild group, the serum inhibin A and activin A of the severe group were significantly high （t=43.88,18.84; P〈0.01）. Inhibin A levels were positively correlated with those of activin A in the two groups, and inhibin A （r=0. 59,0.52; P〈0.01）, activin A levels were positively correlated with the 24-hour proteinuria levels in the study group （r=0.76,0. 56 ;P〈0.01）. The serum inhibin A and activin A in the severe group with fetal growth retardation （FGR） were not significantly different from those without FGR （P〉0.05）. Conclusion Serum levels of inhibin A and activin A are markedly increased in women with preeclampsia, and they are correlated with the degree of severity of the disease.

关 键 词：子痫 抑制素类 激活素类 

分 类 号：R714.2[医药卫生—妇产科学]