藤茶双氢杨梅树皮素抗肝癌H_(22)的实验研究  

The Eperimental Study of Ampelopsin on Antitumor Effect

作　　者：郑作文[1] 阎莉[1] 

机构地区：[1]广西中医学院,广西南宁530001

出　　处：《中医药学刊》2006年第9期1627-1629,共3页Study Journal of Traditional Chinese Medicine

摘　　要：目的:探讨双氢杨梅树皮素(Ampelopsin,APS)的抗肿瘤作用。方法:以MTT法观察APS及其含药血清体外对肝癌H22细胞及对小鼠肝癌H22实体瘤的抑瘤作用。结果:APS及其含药血清均能明显抑制体外培养的H22细胞的生长,APS的IC50为18.65μg/mL,20%、10%含药血清的抑瘤率分别为35.04%、30.91%;APS灌胃给药对荷瘤H22小鼠的肿瘤生长有明显的抑制作用,600mg/kg剂量组的抑瘤率为27.38%。结论:APS对体外H22细胞和体内肝癌H22实体瘤均有抑制作用。Objective ：To investigate the anti- tumor effect of Ampelopsin（APS） in vitro and in vivo. Methods ：Cytotoxitity effect of APS and APS serum on mouse hepatic cancer H22 in mice was observed. Results ： APS could obviously inhibit the growth of cultured H22 cells, the IC50 （48 hours incubation） was 18.65μg/mL. APS serum could also inhibit the H22 cells, the inhibition rates were respectively 35.04%and 30.91% under the serum concentration of 20% and 10%. APS had significant antitumor activity on mice bearing H22. the inhibition rates was 27.38% in 600mg/kg - doses groups. Conclusion ：APS can inhibit the growth of H22 in vitro and in vivo.

关 键 词：蛇葡萄素 抗肿瘤作用 H22 

分 类 号：R-33[医药卫生]