委陵菜三萜类化学成分研究  

Studies on triterpenoids from Potentilla chinensis

作　　者：王庆贺[1] 李志勇[1] 沈阳[2] 林厚文[2] 舒薇[3] 周剑斌[3] 

机构地区：[1]上海交通大学生命科学技术学院,上海200246 [2]第二军医大学长征医院药学部,上海200433 [3]第二军医大学长征医院闸北分院药剂科,上海200070

出　　处：《中国中药杂志》2006年第17期1434-1436,共3页China Journal of Chinese Materia Medica

摘　　要：目的:研究委陵菜的化学成分。方法:运用反复硅胶柱色谱及凝胶柱色谱等色谱技术进行分离纯化,根据波谱数据和理化性质进行结构鉴定。结果:分离鉴定了6个化合物,经波谱方法鉴定为3-羟基-11-烯-11,12-脱氢-28,13-乌苏酸内酯(1),3-O-乙酰坡模醇酸(2),白桦酸(3),3-氧代-12-烯-28-乌苏酸(4),乌苏酸(5),齐墩果酸(6)。结论:以上化合物均为首次从该植物中分离得到,其中化合物1,2,4为首次从该属中分得。Objective： To investigate the chemical constituents of Potentilla chinensis. Method： Silica gel column chromatography and Sephadex LH -20 gel column chromatography were employed for the isolation and purfication. The structures were identified on the basis of spectral data and chemical evidence. Result： Six compounds were isolated and identified as follows： 3-hydroxy-11-ursen-28, 13-olide, 11, 12-dehydroursolic acid lactone （1）, 3-O-acetyl pomolic acid （2）, betulinic acid （3）, 3-oxo-12-ursen-28-oic acid （4）, ursolic acid （5）, oleanic acid （6）. Conelousion： All these compounds were isolated from P. chinensis for the first time, compound 1, 2, 4 were isolated from this genus for the first time.

关 键 词：委陵菜 化学成分 三萜 

分 类 号：R284.1[医药卫生—中药学]