不同配比黄连肉桂煎剂抗心律失常和镇静安神作用的实验研究  

Effects of anti-arrhythmia and tranquilizing the mind of different proportions of Rhizoma Coptidis decoction and Cortex Cinnamomi decoction

作　　者：郭健[1] 席时芳[1] 张莉[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《北京中医药大学学报》2006年第7期454-456,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金课题资助项目(No.39900191)

摘　　要：目的观察不同配比黄连肉桂煎剂的抗心律失常和镇静安神作用。方法采用观察肾上腺素诱发豚鼠心律失常心电图和测定小鼠自主活动、戊巴比妥钠阈下量协同小鼠睡眠的方法。结果黄连肉桂2∶1组能明显缩短心律失常持续时间,明显减少小鼠自主活动次数,促进小鼠睡眠。结论黄连肉桂2∶1组具有抗心律失常和镇静安神作用,效果好于单味黄连和肉桂。Objective To observe the effects of anti-arrhythmia and tranquilizing the mind of different proportions of Rhizoma Coptidis decoction and Cortex Cinnamomi decoction. Methods To observe the ECG of arrhythmia in guinea pigs induced by adrenalin,and determine the mouse autonomic activities and the correlation between sub-threshold dose of pentobarbital sodium and mouse sleep. Results In the group with Rhizoma Coptidis decoction or Cortex Cinnamomi decoction in the proportion of 2 to 1 the period of arrhythmia was shortened significantly in guinea pigs, the frequency of mouse autonomic activities was decreased and the sleep was improved. Conclusion Rhizoma Coptidis decoction and Cortex Cinnamomi decoction in the proportion of 2 to 1 has the effects of anti-arrhythmia and tranquilizing the mind. The effects are better than that of single Rhizoma Coptidis decoction or Cortex Cinnamomi decoction.

关 键 词：黄连肉桂配比 心律失常 镇静安神 

分 类 号：R285.5[医药卫生—中药学]