姜黄素类化合物的抗肿瘤活性  

Anti-tumor activity of curcumin-related compounds

作　　者：王玉玲[1] 吴振[2] 张喜轩[1] 

机构地区：[1]中国医科大学基础医学院化学教研室,辽宁沈阳110001 [2]黑龙江大学化学化工学院有机教研室

出　　处：《中国医科大学学报》2006年第4期380-381,共2页Journal of China Medical University

摘　　要：目的:研究姜黄素类化合物诱导HeLa细胞凋亡及其构效关系。方法:MTT法、Hoechst染色法、DNA凝胶电泳法。结果:姜黄素类化合物可抑制HeLa细胞的生长,诱导HeLa细胞凋亡;琼脂糖凝胶电泳可见典型的DNA带状泳道。结论:姜黄素类化合物可明显地诱导HeLa细胞凋亡,且与其结构有密切关系。Objective： To study the HeLa cell apoptosis induced by curcumin-related compounds and the activity-structure relationship of this compound. Methods： MTT method, morphological observation, agarose gel electrophoresis were performed in this study. Results： Curcumin-related compounds inhibited the growth and induced the apoptosis of HeLa cells. Marked morphological changes, including condensed chromatin, nuclear fragmentation, apoptotic bodies, and DNA ladder in agarose gel, were observed. Conclusion： Curcumin-related compounds could inhibit the apoptosis of HeLa cells, which is correlated with its structure.

关 键 词：抗癌药 姜黄素 活性 

分 类 号：R962[医药卫生—药理学]