格列吡嗪缓释片的制备及其释药特性的研究  

Studies on the Preparation and Release Characteristic of Glipizide Hydrophilic Gel Tablets

作　　者：孙国庆[1] 徐坚[1] 陈琦 赵聪[1] 

机构地区：[1]中国药材大学药剂学教研室

出　　处：《中国药科大学学报》1996年第11期661-664,共4页Journal of China Pharmaceutical University

摘　　要：研究了羟丙甲纤维素（ＨＰＭＣ）水凝胶型格列吡嗪缓释片的制备及其释药特性。结果表明，药物从ＨＰＭＣ水凝胶骨架片中的释放符合零级动力学过程，其零级释药速率受到多种因素，如ＨＰＭＣ的型号、规格、用量，附加剂，制剂的大小与形状及压力的调节和控制。Glipizide hydrophilic gel tablets containing hydroxypropylmethyl-cellulos(HPMC) were prepared, and their drug release characteristic was also evaluated.The results indicated that the drug release process could be best described by zero-order kinetics mechanism.The zero-order release constant might be controlled or adjusted by some formulation and processing factors,such as:type and visocosity of HPMC,HPMC content,presence of additions,compressed force,shape and weight.

关 键 词：格列吡嗪 水凝胶型 缓释片 释药特性 

分 类 号：R944.9[医药卫生—药剂学]