血凝-纤溶动态图在抗凝和溶栓药效研究中的应用Ⅰ  

Application of Coagulo-fibrinolysodynamicogram on Pharmacodynamic Study of Anti-coagulant And Thrombolytic Agents

作　　者：李绍平[1] 季晖[1] 龚小健[1] 李耐三[1] 

机构地区：[1]中国药科大学药理学教研室,南京210009

出　　处：《中国药科大学学报》1996年第12期743-747,共5页Journal of China Pharmaceutical University

摘　　要：对血凝动态图在抗凝药效研究中应用的可行性进行了考察,结果表明:血凝动态图测定参数中,平均凝固速度(ACR)、凝固起动时间(CST)和凝固时间(CT)与抗凝作用密切相关,对药效变化反应灵敏,并呈明显的剂量依赖性(P<0.05)。结果提示:血凝动态图是一简便有效的抗凝药效研究方法,亦适用于中药抗凝有效成分的筛选。Coagulodynamicogram was introduced in the pharmacodynamic research of anti-coagulant. The anti-coagulation effects of four drugs were determined using coagulodynamicogram. The data showed that clot start time(CST), clot time(CT) and average clot rate (ACR), three parameters derived from coagulodynamicogram, are obviously relevant to the anti-coagulation (P<0. 05). The results suggest that coagulodynamicogram is valuable to the pharmacodynamic study of anti-coagulant and the screen of active ingredients in Chinese Traditional Medicine.

关 键 词：血凝纤溶动态图 血凝动态图 抗凝血药 药理学 

分 类 号：R973.2[医药卫生—药品]