胸腺素α1对粤黄鸡免疫功能的调节及机理研究  

Study on the Mechanism and Effect of Thymosin α1 on Immune Function of Yuehuang Chicken

作　　者：冯军[1] 王丙云[1] 计慧琴[1] 陈志胜[1] 陈芳[1] 孙圣兰[2] 江青艳[2] 

机构地区：[1]佛山科学技术学院生命科学院动物医学系,广东佛山528000 [2]华南农业大学动物科学学院,广东广州510642

出　　处：《中国家禽》2006年第16期12-14,18,共4页China Poultry

基　　金：国家自然科学基金农业倾斜项目资助(项目编号:30070557)

摘　　要：实验研究了不同剂量的胸腺素α1(Tα1)对粤黄雏鸡免疫器官指数、组织学结构、外周血和脾脏中T淋巴细胞增殖转化情况以及脾脏抗体形成细胞的影响。结果表明,低剂量(0.015mg/kg体重)Tα1可显著提高鸡免疫器官指数,可使胸腺髓质小体数和淋巴细胞数增加,皮质增宽;脾脏胸腺依赖区和法氏囊依赖区细胞增加,高剂量(0.06mg/kg体重)Tα1则引起法氏囊髓质细胞变性和坏死。结果提示,一定剂量的胸腺素α1可提高鸡的免疫功能。The effects of different dose of thymosin α1 on the immune function of Yuehuang chicken were studied. The low dose of thymosin α1 （0.015 mg/kg）could increase significantly the immune organ indexes of chicken,increase the number of Hassalls corpuscles and lymphocytes within thymus medulla,and broaden the thymus cortex. Thymosin α1 also increased the number of cells within dependent zones of thymus and bursa. But high dose of（0.06mg/kg）thymosin α1 could induce degeneration or necrosis of cells in the bursa of fabricius medulla.The result implied that thymosin α1 could promote the immune function of chicken.

关 键 词：胸腺素Α1 鸡 免疫 

分 类 号：S831.1[农业科学—畜牧学]