转录辅激活因子CBP在脂代谢中的作用  

Function of Transcription Coactivator CBP in Lipid Metabolism

作　　者：苗春木[1] 赵蕾[1] 龚建平[1] 阮雄中[1] 

机构地区：[1]重庆医科大学附属第二医院肝胆外科重庆医科大学脂质研究中心,重庆市400010

出　　处：《医学分子生物学杂志》2006年第5期387-390,400,共5页Journal of Medical Molecular Biology

基　　金：国家自然科学基金重点项目(No.30530360)~~

摘　　要：CREB结合蛋白(cAMPresponseelementbindingproteinbindingprotein,CBP)是一种重要的转录辅激活因子,具有高度保守的序列,能够与300多种转录因子相结合,被认为是哺乳动物基因转录调控中的关键位点。CBP在转录活化过程中主要起乙酰转移酶、桥梁以及支架作用。随着对脂代谢研究的深入,发现很多参与脂代谢的核转录因子(如PPAR、CREB、C/EBPs及SREBPs等)在作用于相应靶基因时都需要CBP的参与,因此CBP可能作为脂代谢的关键调节点。CREB binding protein （CBP） is a crucial transcriptional coaetivator, which contains highly conserved sequence and can interact with about 300 kinds or transcription factors, and is considered to be the key point of the regulation of mammalian genes transcription. CBP functions as acetyltransferase, bridge and scaffold in transcriptional activation. The study of lipid metabolism has found that several transcription factors related to lipid metabolism, such as PPAR, CREB, C/EBPs and SREBPs, were associated with CBP. So we hypothesized that CBP is the key regulator of lipid metabolism.

关 键 词：CREB结合蛋白(CBP) 辅激活因子 脂代谢 

分 类 号：Q71[生物学—分子生物学]