MARCKS及其对树突棘形态的维持作用  

MARCKS and Its Role in the Maintenance of Dendritic Spine Morphology

作　　者：陈枝芳[1] 徐亮[1] 陆佩华[1] 

机构地区：[1]上海交通大学医学院神经生物学实验室,上海市200025

出　　处：《医学分子生物学杂志》2006年第5期394-396,共3页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展规划项目(973计划)(No.2003CB5153O2)~~

摘　　要：MARCKS是一种分子量为32ku的膜内蛋白,在组织中广泛表达,但主要高表达在脑内的轴突、小直径的树突和树突棘。MARCKS是作为PKC的重要底物被发现的,它可同时与细胞膜和肌动蛋白细胞骨架结合。新近研究表明,以MARCKS为底物的PKC介导的信号调节途径既可以影响肌动蛋白细胞骨架,又可以影响细胞膜的动力学,在维持神经元树突棘的独特形态中起着重要作用。MARCKS （myristoylated alanine-rich C kinase substrate） is a 32 kDa ubiquitously expressed membrane-bound protein. It is highly expressed in axons, small dendrites and dendritic spines in the brain. MARCKS was found as a major substrate for PKC. It associates with the membrane and binds to the actin cytoskeleton, regulates the signal transduction between them, thereby affecting the dynamics of cytoskeleton and membrane. Recent studies have indicated that MARCKS plays an essential role in maintaining the morphology of dendritic spine.

关 键 词：MARCKS蛋白 树突棘 肌动蛋白 细胞骨架 细胞膜 

分 类 号：Q291[生物学—细胞生物学]