氟比洛芬脂质体的制备和体外透皮实验  

Preparation and transdermal diffusion of flurbiprofen liposomes

作　　者：殷丹[1] 李三鸣[1] 代奕[1] 余李敏[1] 赵海波[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2006年第9期553-556,561,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的研究氟比洛芬脂质体的制备和体外透皮扩散。方法乙醇注入法制备不同粒径的氟比洛芬脂质体,微型柱离心法分离脂质体和游离药物,采用Franz扩散池,考察氟比洛芬脂质体透过单位面积鼠皮的累积量、渗透系数和皮内滞留量。结果相对于大粒径脂质体,小粒径脂质体显著提高氟比洛芬的透皮速率;开放式给药组的累积透过量、渗透系数和皮内滞留量高于封闭组。结论脂质体给药方式和脂质体的粒径是影响氟比洛芬体外透皮的主要因素。Objective To investigate the preparation method and the transdermal diffusion of flurbiprofen liposomes. Methods Various particle sizes of flurbiprofen liposomes were prepared using the ethanol injection method. The minicolumn centrifugation method was used to separate the free flurbiprofen from liposomes. Amended Franz diffusion cell and rat skin were used to investigate the cumulative amount, release rate and amount in skin. Results The smaller particle size liposomes could increase the penetration ability of flrubiprofen into the skin compared with the larger ones. When donor compartment was nonocclusive, the cumulative amount was higher compared with occlusive one, the same results were obtained for the release rate and amount in skin. Conclusions Application condition and particle size of liposomes play a main role in the penetration of flrubiprofen liposomes through excised rat skin in vitro.

关 键 词：氟比洛芬 脂质体制备 包封率 透皮扩散 

分 类 号：R94[医药卫生—药剂学]