环糊精包合物脂质体给药系统的研究进展  

Advances in liposome entrapped drug cyclodextrin complex delivery systems

作　　者：王志宣[1] 邓英杰[1] 张晓鹏[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2006年第9期607-612,共6页Journal of Shenyang Pharmaceutical University

摘　　要：目的介绍环糊精包合物脂质体给药系统的研究进展。方法根据近年来的21篇文献资料进行归纳整理、分析评述。结果环糊精包合物脂质体能够提高脂质体载药量,改善脂质体中药物泄漏,提高药物在血浆中的稳定性和药效。结论环糊精包合物脂质体是一种新型的药物载体,具有广阔的研究与应用前景。Objective To introduce the progress of llposome entrapped cyclodextrin complex delivery systerm. Methods The preparation methods, characteristics and the applications of liposome entrapped cyclodextrin complex in pharmaceutics were reviewed. Results Liposome entrapped cyclodextrin complex could increase the drug loading amount, decrease the leakage of drug in liposome, improve the stability of drug in plasma and improve its pharmacokinetics. Conclusions As a new drug delivery system, liposome entrapped cyclodextrin complex has a good prospect in pharmaceutical field.

关 键 词：脂质体 环糊精 给药系统 

分 类 号：R944.9[医药卫生—药剂学]