5-(3-吡啶基)-2-芳酰氨基-1,3,4-噻二唑的合成及生物活性  

Synthesis and Biological Activity of 2-Aroylamino-5-(pyrid-3-yl)-1,3,4-thiadiazoles

作　　者：谭小红[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《湖北民族学院学报（自然科学版）》2006年第3期268-270,共3页Journal of Hubei Minzu University(Natural Science Edition)

基　　金：湖北省教育厅科学研究计划项目(Q200529003)

摘　　要：利用2-氨基-5-(3-吡啶基)-1,3,4-噻二唑和取代苯甲酰氯的酰化反应,合成了5个5-(3-吡啶基)-2-芳酰氨基-1,3,4-噻二唑类化合物Ⅲa^e,其结构经1H NMR、IR和元素分析方法证实.初步的生物活性测定试验表明,II-Ic具有优良的生长素活性,在10mg.L-1浓度下其促进率达到40%以上.Abstract： Five derivatives of 2-aroylamino-5-（ pyrid-3-yl）-1,3,4-thiadiazoles Ⅲa-e have been synthesized by amidation of 2-amino-5-（ pyrid-3-yl）-1, 3,4-thiadiazoles and substituted benzoyl chloride. The structures of all these compounds were confirmed by ^1H NMR,IR and elementary analysis. It is found from the results of preliminary biological activity tests that Ⅲc has an excellent auxin activity, whose promoting effect could reach above 40% at the concentration of 10 mg·L^-1

关 键 词：芳酰氨基 噻二唑 合成 生长素 细胞分裂素 

分 类 号：O621.29[理学—有机化学]