新型亲核NO供体Diazeniumdiolate及其靶向性控释材料  

NO Releasing Diazeniumdiolates and Targeting NO Releasing Materials

作　　者：高群[1] 万锕俊[1] 

机构地区：[1]上海交通大学化学化工学院,上海200240

出　　处：《化学进展》2006年第9期1101-1109,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20376045);上海纳米重大专项项目(No.0452nm037)资助

摘　　要：新型亲核NO供体diazeniumdiolate独特的化学结构和性质,使其成为目前NO供体研究的一个热点。要使其成为更有效的药物,它的靶向性和控释性能是当前研究的重点,减小亲核试剂(多胺)的细胞毒性和亚硝胺的生成是研究的难点。本文对增强靶向性释放所采取的三个措施(聚合物控释、特定酶代谢释放和光降解释放)的近十几年国外的研究情况进行了综述。Chemical structures and materials capable of targeting reliable and properties of diazeniumdiolates that make them so excellent for designing controllable fluxes of bioactive NO have become one of the forefronts and highlights of novel NO donors. The toxicity and poor biocompatibility of the nucleophile （polyamines） and the formation of potentially carcinogenic nitrosoamine are the problems associated with its successful clinical application. Recent research progress on targeting nitric oxide releasing materials is reviewed, basing on the three strategies of delivering NO specifically to a targeted site, including polymer-based diazeniumdiolates, enzyme activated diazeniumdiolates and photosensitive diazeniumdiolates.

关 键 词：一氧化氮 NO供体 diazeniumdiolates 亲核试剂 靶向性释放 

分 类 号：O613.61[理学—无机化学] TQ126[理学—化学]