非离子胶束对竹红菌乙素及其溴代物基态和激发态的保护作用  

PROTECTIVE EFFECTS OF NONIONIC MICELLE ON GROUND AND EXCITED STATES OF HYPOCRELLIN B AND ITS BROMINATED PRODUCTS

作　　者：张红雨[1] 张志义[1] 万谦[1] 王大辉[1] 李美芬[1] 

机构地区：[1]中国科学院生物物理研究所

出　　处：《感光科学与光化学》1996年第2期138-143,共6页Photographic Science and Photochemistry

基　　金：国家自然科学基金

摘　　要：本文用ＴｒｉｔｏｎＸ－１００非离子型胶束增溶竹红菌乙素（ＨＢ）及其两种溴代物（５－Ｂｒ－ＨＢ，５，８－ｄｉＢｒ－Ｈ８），发现该胶束对ＨＢ的基态和激发态都有保护作用：（１）ＨＢ基态的ρＫａ值升高；（２）荧光量子产率增大。这使其光敏反应产生的活性中间体￣１Ｏ＿２和·ＯＨ的产额增加，从而增强了其光敏活性，实验还发现，这种胶束对ＨＢ的两种溴代物的激发态亦有保护作用，且强于ＨＢ，这导致它们Ｏ＿２和·ＯＨ的产额显著高于ＨＢ。￣１Ｏ＿２和·ＯＨ产额的提高，在光敏损伤作用中具有重要的生物学意义。In this paper Triton X-100 nonionic micelle is used to solubilize hypocrellin B(HB)and its brominated products(5-Br-HB and 5,8-diBr-HB).It is found that micelle possess protective effects on ground and excited states of HB:(1)enhancing the ρKa value of ground state;(2)increasing the yields of fluorescence and active intermediates(·OH)produced during photosensitization. So it raises the photosensitizing activity of HB. In addition,micelle also possess protective effect on two kinds of brominated HB, and which is higher than that on HB. This leads to their higher yields of active intermediates(·OH)than HB,which is of great importance in photosensitizing damage.

关 键 词：胶束 竹红菌乙素 基态 激发态 溴代物 光疗法 

分 类 号：R454.2[医药卫生—治疗学]