大鼠侧脑室及鞘内注射孤啡肽减弱电针镇痛效应  

Intrathecal or Intracerebroventricular Injection of OFQ Attenuates Acupuncture Analgesia on Rats

作　　者：张秀琳[1,2] 朱崇斌[1,2] 吴根诚[1,2] 许绍芬[1,2] 曹小定[1,2] 

机构地区：[1]济南市解放军济南医高专 [2]上海市上海医科大学

出　　处：《解放军医学高等专科学校学报》1996年第4期12-15,共4页Clinical Journal of Medical Officer

摘　　要：在大鼠电刺激甩尾测痛模型上，观察了侧脑室（ＩＣＶ）及鞘内（ＩＴ）注射孤啡肽对电针镇痛的影响。结果表明，大鼠ＩＣＶ及ＩＴ注射１μｇ（０．５５ｎｍｏｌ）孤啡肽（ＯＦＱ）均可降低痛阈，ＩＴ注射１μｇＯＦＱ减弱电针镇痛效应。ＩＣＶ注射１μｇＯＦＱ可反转电针镇痛作用。提示中枢ＯＦＱ不利于电针镇痛。In present study, the effects of OFQ on acupuncture analgesia(AA) were observed by using tail flick test.It was found that intrathecal(IT) or intracerebroventricular (ICV) injection of lug OFQ reduced pain threshold of the rats, IT injection of OFQ attenuated AA, and ICV injection of OFQ antagonized AA.The results in present study suggests that central OFQ is one of the unfavorable factors to AA.

关 键 词：孤啡肽 中枢神经系统 针刺镇痛 药理学 

分 类 号：R977.6[医药卫生—药品] R246.2[医药卫生—药学]