Transfusion transmitted virus: A review on its molecular characteristics and role in medicine  

作　　者：M Irshad YK Joshi Y Sharma I Dhar 

机构地区：[1]Clinical Biochemistry Division Department of Laboratory Medicine,All India Institute of Medical Sciences,New Delhi-110029,India [2]Department of Gastroenterology and Human Nutrition All India Institute of Medical Sciences,New Delhi-110029,India

出　　处：《World Journal of Gastroenterology》2006年第32期5122-5134,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by Indian Council of Medical Research, New Delhi-110049 for financial support

摘　　要：The present review gives an updated overview of transfusion transmitted virus （TTV）, a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. TTV, a DNA virus, is a single stranded, non-enveloped, 3.8 kb long DNA virus with a small and covalently closed circular genome comprising 3852 bases. It was tentatively designated Cirdnoviridae virus.TTV genome sequence is heterogeneous and reveals the existence of six different genotypes and several subtypes. TTV has been reported to transmit not only via parenteral routes, but also via alternate routes. This virus has been detected in different non-human primates as well. At present, TTV is detected by polymerase chain reaction （PCR） with no other available diagnostic assays. It shows its presence globally and was detected in high percent populations of healthy persons as well as in various disease groups. Initially it was supposed to have strong association with liver disease; however, there is little evidence to show its liver tropism and contribution in causing liver diseases. It shows high prevalence in hemodialysis patients, pointing towards its significance in renal diseases. In addition,TTV is associated with several infectious and non-infectious diseases. Though, its exact pathogenesis is not yet clear, TTV virus possibly resides and multiplies in bone marrow cells and peripheral blood mononuclear cells （PBMCs）. Recently, attempts have been made to eradicate this virus with interferon treatment. More information is still needed to extricate various mysteries related to TTV.现在的评论给输送的更新的概述播送病毒(TTV ) ，一个新奇代理人在与它的分子的特征的关系，流行病学的特征，传播的模式，组织向性，致病，在各种各样的疾病的角色和它从身体的根除。TTV，一个 DNA 病毒，一个单身者被搁浅，非包，有包括 3852 的一个小、 covalently 关上的圆形的染色体的长 DNA 病毒基于的 3.8 kb。它是尝试性地指明的 Circinoviridae 病毒。TTV 染色体顺序是异构的并且揭示六不同遗传型和几种子类型的存在。TTV 被报导了不仅经由非肠道的线路，而且经由交替的线路播送。这个病毒也在不同非人类的首领被检测了。目前， TTV 被聚合酶链反应(PCR ) 没有另外的可得到的诊断试金检测。它全球性显示出它的存在并且在健康的人的高百分比人口以及在各种各样的疾病组被检测。开始，它应当与肝疾病有强壮的协会；然而，几乎没有小证据在引起肝疾病显示出它的肝向性和贡献。它在牙齿过敏细胞溶解病人显示出高流行，向它在肾的疾病的意义指。另外， TTV 与几传染、非传染的疾病被联系。不过，它的准确致病是还没清楚的， TTV 病毒可能住并且在骨髓房间和外部血乘单音的原子房间(PBMC ) 。最近，被尝试了根除有干扰素治疗的这个病毒。更多的信息仍然被需要解脱与 TTV 有关的各种各样的谜。

关 键 词：Transfusion transmitted virus DNA VIRUS HEPATITIS TRANSFUSION 

分 类 号：R373[医药卫生—病原生物学]