红芽大戟的化学成分  

Chemical constituents of Knoxia valerianoides

作　　者：袁珊琴[1] 赵毅民[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《药学学报》2006年第8期735-737,共3页Acta Pharmaceutica Sinica

摘　　要：目的研究茜草科植物红芽大戟Knoxia valerianoidesThorel et P itard的化学成分。方法采用各种色谱技术进行分离纯化,经光谱数据分析鉴定其结构。结果分离得到3个蒽醌类化合物:1,3,5三-羟基-2甲-基-6-甲氧基蒽醌(红大戟素,I),1,3,6三-羟基-5-乙氧甲基蒽醌(II)及1,3二-羟基-2甲-基蒽醌(甲基异茜草素,III)。结论II为新化合物。Aim To study the chemical constituents of Knoxia valerianoides Thorel et Pitard. Methods Chromatographic methods were used for the isolation and purification. Structures were elucidated on the basis of chemical analysis and spectroscopic data. Results Three anthraguinones were isolated from K. valerianoides and identified as 1, 3, 5-trihydroxy-2-methyl-6-methoxyl-anthraguinone （kaoxiadin,Ⅰ） , 1,3,6-trihydroxy-5-ethoxylmethyl-anthraguinone （ Ⅱ ） and 1,3-dihydroxy-2-methyl- anthraguinone （rubiadin, Ⅲ）. Conclusion Compound II is a new anthraguinone constituent.

关 键 词：红芽大戟 1 3 6-三羟基-5-乙氧甲基蒽醌 蒽醌类化合物 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]