诺必擂停对肝癌Heps的抑制作用及其机制  

Antitumor effects of nobiletin on Heps and its mechanism

作　　者：张洪泉[1] 葛慧[1] 成美英[1] 

机构地区：[1]扬州大学医药研究所,江苏扬州225001

出　　处：《药学学报》2006年第8期797-800,共4页Acta Pharmaceutica Sinica

摘　　要：Aim To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice.Methods Models of Heps tumor bearing mice were established.The inhibitory rates of tumor growth were calculated,the apoptosis morphology of tumor tissue was observed.The T lymphocyte transformation capacity was tested by MTT assay,the TNFα and IL-2 production were measured by LDH kits.Results Nobiletin could significantly inhibit Heps tumor growth.The inhibitory rates were 42.14%-65.09%(P<0.01).The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope.Nobiletin could stimulate T lymphocyte transformation and the production of TNFα and IL-2.Conclusion Nobiletin has obvious antitumor effect on Heps,the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.Aim To study the inhibitory effect and mechanism of nobiletin on Heps tumor bearing mice. Methods Models of Heps tumor bearing mice were established. The inhibitory rates of tumor growth were calculated, the apoptosis morphology of tumor tissue was observed. The T lymphocyte transformation capacity was tested by MTT assay, the TNFα and IL-2 production were measured by LDH kits. Results Nobiletin could significantly inhibit Heps tumor growth. The inhibitory rates were 42. 14% -65.09% （P 〈 0.01 ）. The morphology of tumor tissues in nobiletin group had typical characters of necrosis and apoptosis through transmission electron microscope. Nobiletin could stimulate T lymphocyte transformation and the production of TNFα and IL-2. Conclusion Nobiletin has obvions antitumor effect on Heps, the main mechanism is to enhance the cellular immune function and induce apoptosis of tumor tissue.

关 键 词：诺必擂停 肝癌实体型 细胞凋亡 

分 类 号：R967[医药卫生—药理学]