阿托伐他汀对自发性高血压大鼠动脉血压和血管内皮功能的影响  

Effects of atorvastatin on aortic blood pressure and vascular endothelial function in spontaneously hypertensive rats

作　　者：葛长江[1] 胡申江[1] 吕树铮[2] 陈韵岱[2] 

机构地区：[1]浙江大学医学院附属第一医院心内科,杭州310003 [2]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《中华神经医学杂志》2006年第9期907-910,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(30470715)

摘　　要：目的探讨阿托伐他汀对自发性高血压大鼠(SHR)动脉血压和血管内皮功能的影响。方法选用8周龄SHR12只,随机分为阿托伐他汀治疗组(ATV组,n=6)、蒸馏水组(DW组,n=6),另选6只WKY大鼠作为正常对照。ATV组大鼠给以阿托伐他汀50mg/(kg·d)加适量蒸馏水灌胃。DW组和WKY组每天同时用等量蒸馏水灌胃。观察给药前后大鼠尾动脉血压的变化,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)浓度,观察血浆内皮素1(ET-1)水平、主动脉组织一氧化氮合酶(NOS)活性的变化特点。结果ATV组大鼠动脉血压显著低于DW组(P＜0．01)；与DW组和WKY组比较,ATV组血清TC、TG和HDL-C浓度显著降低(P＜0．01,P＜0．05)；DW组血清ET-1水平显著高于WKY组(P＜0．05),主动脉组织NOS活性显著低于WKY组(P＜0．05),经ATV治疗后血清ET-1水平明显降低(P＜0．05),而主动脉组织NOS活性显著增高(P＜0．01)。结论长期应用阿托伐他汀可以显著降低动脉血压。阿托伐他汀通过改善血管内皮功能延缓高血压的病理过程。Objective To evaluate the effects of atorvastatin on aortic blood pressure and vascular endothelial function in spontaneously hypertensive rats （SHR）. Methods The 8-week-old SHR were randomized into atorvastatin treated group （ATV group, n=6）, distilled water group （DW group, n=6）, and Wistar-Kyoto （WKY） rats as normal controls. Atorvastatin [50 mg/（kg·d）] and appropriate amounts of distilled water were administered to ATV group for 10 weeks by garage. Blood pressure of caudal artery was examined before and after treatment, and serum titres of total cholesterol （TC）, triglycerides （TG）, high density lipoprotein-cholesterol （HDL-C） and changes of serum endothelin-1 （ET-1）, activity of nitric oxide synthase （NOS） in aorta tissue were measured. Results Blood pressure in ATV group was much lower than that in DW group （P〈0.01）. Compared with DW group and WKY group, serum titres ofTC, TG and HDL-C in ATV group were significantly lower （P〈0.01, P〈0.05）. Serum level of ET-1 was significant higher in DW group than in WKY group （P〈0.05）, and the activity of NOS in aorta tissue was remarkedly reduced （P〈0.05）. However, serum level of ET-1 was decreased （P〈0.05） while the activity of NOS in aorta tissue was elevated after treatment with ATV （P〈0.01）. Conclusion Long-term administration of atorvastatin can effectively reduce blood pressure. Atorvastatin may delay pathological progress of hypertension by ameliorating vascular endothelial function.

关 键 词：阿托伐他汀 高血压 血管平滑肌 内皮素 一氧化氮 

分 类 号：R544.1[医药卫生—心血管疾病]