吸收与代谢后寡单体复合药物——中药现代化的新尝试  

Post-absorption/metabolism multicompound drug: a new approach to modernization of Chinese herbal medicine

作　　者：贾韦国[1] 

机构地区：[1]加拿大不列颠哥伦比亚大学医学院

出　　处：《中西医结合学报》2006年第5期441-446,共6页Journal of Chinese Integrative Medicine

摘　　要：传统中医药现代化的主要困境在于天然药物必然的化学成分的不可控性。本文提出了一类新型药物的概念:吸收与代谢后寡单体复合药物(post-absorption/metabolismmulticompounddrug,PAMD)。PAMD符合现代西药所有的标准,同时,它仍然保留了中药配伍的基本精髓,通过多种药材的组合而达到多重药理机制的有机协同。PAMD的概念是基于口服中药的大部分组分由于肠道吸收率极低根本不能到达血液,而在血液或靶器官中能找到的仅仅是少数的组分,或更可能的是这些组分的代谢物。只有这些经过吸收代谢后的化合物才发挥其治疗作用。由于这些化合物的数量有限,在分离、纯化并了解其药理作用的基础上,将纯化后的这些化合物以一定比例重新组合起来,就可以组成一个与原有的中药在理论上具有同等或更佳疗效的新型复合药物。本文对PAMD的研制途径和可能遇到的困难也进行了探讨。A major hurdle that humbles the modernization of traditional Chinese herbal medicine （OHM） is the inconsistency of chemical composition, which is inevitable due to the natural origins of OHM. Here I propose a concept of a new category of drugs, named ＂post-absorption/metabolism multicompound drug （PAMD）＂ that will meet every standard of modern pharmaceuticals, yet maintain the fundamental principle of traditional Chinese medicine, which is an integrative therapeutic approach through multiple mechanisms by a cocktail of various herbs. The PAMD concept is based on the fact that the most of chemical ingredients in an orally taken OHM remedy may never enter the blood stream owing to the poor gastrointestinal absorption. Only a few original ingredients or, most likely, a few metabolites of those absorbed ingredients are found in the blood or target organs. The compounds after the absorption/metabolic process are the only ones responsible for pharmacological functions of the remedy. Given the limited number of species, those compounds, once isolated and tested for their pharmacological activity, can be formulated with designed ratios to form new drugs that should theoretically possess an equivalent or better therapeutic efficacy than the original OHM remedy. Strategies of developing PAMDs and possible difficulties are also discussed.

关 键 词：吸收 代谢 复合药物 中药 现代化 

分 类 号：R28[医药卫生—中药学]