进入细胞核之门:核移位机制研究进展  

Through The Door to The Nucleus:Progress on Nuclear Translocation Mechanism

作　　者：罗湘建[1] 曹亚[1] 

机构地区：[1]中南大学湘雅医学院肿瘤研究所,长沙410078

出　　处：《生物化学与生物物理进展》2006年第9期834-837,共4页Progress In Biochemistry and Biophysics

摘　　要：细胞中DNA复制和RNA生物形成发生在细胞核,而蛋白质的合成场所位于细胞质,这些生命活动的整合依赖于功能蛋白等在两个亚空间尺度的选择性穿梭.这是一个信号介导的过程,需要能量和可溶性因子如穿梭载体的参与.通过介绍功能蛋白受控核移位机制研究进展,拓宽了其潜在的医学应用,该领域的深入研究,将有力推动抗病毒治疗和基因治疗载体的设计研究.DNA replication and RNA biogenesis happen in the cell nucleus,while protein synthesis occurs in the cytoplasm. Integration of these activities depends on function proteins＇ selective transport between the two sub-dimensions. It is a signal mediated process, which needs energy and the participation of soluble factors. By introduction of progress on function protein regulated nuclear translocation, its potential medical application has been explored. With deeper investigation in this field, it will significantly promote the design of anti-virus and gene vector therapy.

关 键 词：核孔复合物(NPC) GTP酶Ran 核定位信号序列(NLS) 核移位 

分 类 号：Q291[生物学—细胞生物学]