白木通中一个新的三萜皂苷类化合物  

A new triterpenoid saponin from stems of Akebia trifoliata

作　　者：高慧敏[1] 王智民[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《药学学报》2006年第9期835-839,共5页Acta Pharmaceutica Sinica

基　　金：国家高技术研究发展计划(863计划)创新药物和中药现代化资助项目(2004AA223730-14)

摘　　要：目的研究木通科植物白木通藤茎的化学成分。方法通过反复硅胶柱色谱、ODS柱色谱和重结晶等方法进行分离纯化,根据化合物的理化性质和波谱数据鉴定结构。结果从白木通藤茎70%乙醇提取物中分离得到6个化合物。分别鉴定为2,α3,β23-trihydroxyolean-12-en-28-oic ac idO-β-D-xylopyranosyl-(1→3)-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(I),2,α3,β23-trihydroxyurs-12-en-28-oic ac idO--βD-xylopyranosyl-(1→3)-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(II),2α,3,β23-trihydroxyolean-12-en-28-oic ac idO-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosylester(III),2,α3,β23-trihydroxyurs-12-en-28-oic ac idO-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(IV),2,α3,β23-trihydroxyolean-12-en-28-oic ac idO--βD-glucopyranosyl ester(V),2,α3,β23-trihydroxyurs-12-en-28-oic ac idO-β-D-glucopyranosyl ester(V I)。结论化合物II为新化合物,命名为mutongsapon inC,其他均为首次从该植物藤茎中分离得到。Aim To study the chemical constituents of the stems of Akebia trifoliata （ThuMb.） Koidz. var. australis （Diels） Rehd, Methods The compounds were isolated and purified by recrystallization and chromatography on silica gel and ODS column. Their structures were elucidated on the basis of physicochemical properties and spectral analysis. Results Six compounds were identified as 2 α, 3 β,23-trihydroxyolean-12-en-28-oic acid O- β-D-xylopyranosyl- （ 1 → 3 ） - O- α-L-rhamnopyranosyl- （ 1 → 4 ） - O- β-D-glucopyranosyl- （ 1 →6 ） - β-D-glucopyranosyl ester （ Ⅰ）, 2 α, 3β,23-trihydroxyurs-12-en-28-oic acid O- β-O-xylopyranosyl-（ 1 → 3 ）-O- α-L-rhamnopyranosyl-（ 1 → 4 ）-O- β-O-glucopyranosyl-（ 1 → 6 ）-/3-D- glueopyranosyl ester （Ⅱ） , 2 α, 3 β,23-trihydroxyolean- 12-en-28-oie acid O- α-L-rhamnopyranosyl- （ 1→4 ） - O- β-D-glueopyranosyl- （ 1 →6 ） - β-D-glueopyranosyl ester （ Ⅲ）, 2 α, 3/3,23 -trihyd roxyurs- 12-en-28 -oie acid O-α-L-rhamnopyranosyl-（ 1→4 ） -O-β-D-glucopyranosyl- （ 1→6 ） -β-D-glucopyranosyl ester （ Ⅳ ）, 2α, 3β, 23-trihydroxyolean-12-en-28-oic acid O-β-D-glucopyranosyl ester （Ⅴ） , 2α,3β,23-trihydroxyurs-12-en-28- oic acid O-β-D-glucopyranosyl ester （Ⅵ）. Conclusion Compound II, named mutongsaponin C, is a new triterpenoid saponin and others were isolated from the stems of Akebia trifoliata （Thunb.） Koidz. var. australis （Diels） Rehd for the first time.

关 键 词：木通科 白木通 三萜皂苷 mutongsaponin C 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]