中药色谱指纹图谱潜信息特征判据研究  

The digital criterion of the potential information characteristics of the traditional Chinese medicine chromatographic fingerprints

作　　者：孙国祥[1] 侯志飞[1] 毕雨萌[1] 毕开顺[1] 孙毓庆[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《药学学报》2006年第9期857-862,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重大研究计划项目(90612002)

摘　　要：目的对中药色谱指纹图谱潜信息特征进行判据研究,用F和I等37个指标揭示色谱指纹图谱的潜信息特征。方法用银杏叶提取物(GBE)、银杏达莫注射液(GLED I)和苦碟子(ISH)与苦碟子注射液(ISH I)的HPLC指纹图谱进行比较研究。结果从积分信号强度、信号均化程度、分离度、指纹信息量等多方面综合评价出GBE指纹图谱好于GLED I,ISH指纹图谱好于ISH I,GBE与ISH指纹图谱基本相当。结论F和I等37个指标可客观、真实、全面地揭示中药指纹图谱的潜信息特征。Aim To exploit the characteristic digital criterion for the potential information characteristics of traditional Chinese medicine chromatographic fingerprints, the 37 parameters such as F and I were firstly proposed to disclose the potential information characteristics of traditional Chinese medicine fingerprints. Methods The HPLC fingerprints of the Ginkgo biloba extract （GBE） , Ginkgo leaf extract and diphyridamole injection （GLEDI） , lxeris sonchifolia Hance （ISH） and lxeris sonchifolia Hance injection （ISHI） were compared each other. Results As far as the peak signal intensity, the uniform of peak signal, resolution and the fingerprint information were concerned. The GBE fingerprint was better than the GLEDI＇ s, and the ISH fingerprint was also better than the ISHI＇ s, then GBE fingerprint was close to the ISHI＇ s. Conclusion The 37 parameters such as F and I can be used to objectively, authentically and thoroughly display the potential information characteristics of the traditional Chinese medicine chromatographic fingerprints.

关 键 词：中药色谱指纹图谱 潜信息特征 数字化判据 苦碟子 银杏叶提取物 

分 类 号：R927.11[医药卫生—药学] R284.1