静脉滴注右旋糖酐铁注射液治疗慢性肾功能不全伴肾性贫血的临床疗效  

Clinical effects of intravenous iron dextran for the treatment of renal anemia concomitant with chronic renal failure

作　　者：张耀全[1] 王代红[1] 周剑峰[1] 袁发焕[1] 

机构地区：[1]中国人民解放军第三军医大学新桥医院肾内科

出　　处：《中国临床药学杂志》2006年第5期271-274,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的观察静脉滴注(静滴)右旋糖酐铁注射液治疗慢性肾功能不全伴缺铁性贫血的疗效及安全性。方法103例慢性肾功能不全伴贫血患者,随机分为静滴组和肌注组。静滴组用进口右旋糖酐铁注射液100mg溶于100mLNS,ivgtt,每周2次;肌注组用国产右旋糖酐铁注射液100mg,im,每周2次,疗程均10wk。观察治疗前后红细胞计数(RBC)、血红蛋白(Hb)、血细胞比容(Hct)、血清铁蛋白(SF)、转铁蛋白饱和度(TSAT)、肝肾功能及药物不良反应。结果65例患者完成本研究,其中静滴组30例,肌注组35例。静滴组不良反应发生率为6.0%,低于肌注组(18.9%),P<0.01。治疗10wk后,2组贫血症状均有明显改善。静滴组SF、TSAT、Hb、Hct分别为(516.8±68.8)μg·L-1、(34.5±7.2)%、(88.8±14.4)g·L-1、(27.2±3.2)%;肌注组分别为(426±88.7)μg·L-1、(30.2±5.8)%、(79.0±11.4)g·L-1、(24.9±3.1)%,2组相比差异有统计学意义(P<0.05或P<0.01)。结论静滴右旋糖酐铁注射液治疗慢性肾功能不全伴缺铁性贫血是有效、安全的。A/M To investigate the efficacy and safety of intravenous iron dextran for the treatment of renal anemia in chronic renal failure patients. METHODS One hundred and three renal anemia patients with chronic renal failure were divided into intravenously guttae（ iv gtt, imported drug） group and intramuscular injection（ im, domestic drug） group randomly. 100 mg iron dextran that was dissolved in 100 mL of 0.9% NaCl solution was used twice a week in iv gtt group; 100 mg iron dextran was injected by the patients in im gorup twice a week and 10 wk in total. The levels of serum ferritin（SF）, transferrin saturation（TSAT）, hemoglobin（Hb） and hematocrit（Hct） were tested before and after the treatment and the adverse drug reaction was observed. RESULTS Sixty five patients completed the study and there were thirty and thirty five patients in the iv gtt group and im group respectively. The incidence rate of adverse drug reactions in iv gtt group （6.0%）was significantly lower than that in im group （ 18.9%, P 〈 0.01 ）. The anaemia of each group was improved after treatment. At the end of the trial, the levels of SF, TSAT, Hb and Hct in the iv gtt group and im group were （516.8±68.8）μg·L^-1 vs （426±88.7）μg·L^-1,（34.5 ±7.2）% vs （30.2±5.8）%, （88.8±14.4）μg·L^-1 vs （79.0± 11.4）μg·L^-1, （27.2 ± 3.2）% vs （24.9 ± 3.1）% ,respectively. There were significant differences between 2 groups（ P 〈 0.05 or P 〈 0.01 ）. CONCLUSION Intravenous iron dextran can effectively increase serum iron parametersand hemoglobin levels in patients with chronic renal failure and the incidence rote of adverse drag reaction is lower in curing renal anemia.

关 键 词：慢性肾功能不全 贫血 右旋糖酐铁 

分 类 号：R692.5[医药卫生—泌尿科学]