血液透析与血液透析滤过急性肾衰竭患儿治疗前后血清β_2微球蛋白下降率对比  

Contrast Research on Decreasing Rate of Serum β_2-Microglobulin before and after Children′s Hemodialysis and Hemodiafiltation

作　　者：李翠华[1] 栾江威[1] 吴燕祥[1] 杨杏鲜[1] 王筱雯[1] 

机构地区：[1]武汉市儿童医院肾脏内科,武汉430016

出　　处：《实用儿科临床杂志》2006年第18期1242-1243,共2页Journal of Applied Clinical Pediatrics

基　　金：武汉市卫生局临床重点学科研究项目资助[武卫(2004)241]

摘　　要：目的探讨血液透析(HD)及血液透析滤过(HDF)治疗急性肾衰竭患儿前后血清β2微球蛋白(β2-MG)及下降率的影响。方法对各种原因导致的急性肾衰竭需行血液净化治疗38例患儿随机分成2组。HD组20例,HDF组18例。透析前后分别测血清β2-MG水平。结果HDF与HD前后血清β2-MG变化经统计学处理,HDF组治疗前后血清β2-MG水平差异有显著性意义(P<0.01);HD组治疗前后血清β2-MG水平差异无显著性意义(P>0.05);HDF和HD组治疗后比较血清β2-MG水平差异、下降率差异均有显著性意义(P均<0.01)。结论HDF清除血β2-MG明显优于HD。Objective To explore the influence of hemodialysis（HD） and hemodiafiltation on serumβ2 - microglobulin（β2 - MG） of children with acute renal failure and contrast research on declining rate of serum β2 - MG before and after children＇s HD and HDF. Met- hods By Branc Dialog HD machine of double - pump, HDF for 18 times and HI） for 20 times were given to children with acute renal failure. The serum β2 - MG were observed before and after HD and HDF. Results A great difference was observed in level of serum β2 - MG between before and after HD and HDF. In HDF group ,there was significant difference in level of serum β2 - MG before and after HDF （P〈 0.01 ）; In HD group, there was no significant difference in level of serum β2 - MG before and after HD（ P 〈 0.05）. Compared with decreasing rate of serum β2 - MG before and after HDF and HD, HDF was higher than HD （P 〈 0, 01 ）. Compared with decreasing rate of serum β2 - MG between before and after HD and HDF, HDF was higher than HI） （ P〈 0.01 ）. Conclusion HDF is better clearance effect on low - molecular - weight protein and serum β2 - MG than that of HD.

关 键 词：血液透析 血液透析滤过 Β2-微球蛋白 儿童 

分 类 号：R726.9[医药卫生—儿科]