具有优异淋巴示踪特性的纳米炭混悬液的制备  

Preparation of carbon nanoparticle suspension with excellent lymphatic tracing properties

作　　者：谢永美[1] 唐小海 何俊[1] 成明[1] 郑开波[1] 张勇 

机构地区：[1]四川大学化学学院,四川成都610064 [2]成都市药友科技发展有限公司,四川成都610041

出　　处：《新型炭材料》2006年第3期259-262,共4页New Carbon Materials

摘　　要：为了得到具有优异淋巴示踪特性的炭黑(CB),利用浓硝酸在100℃下氧化炭黑100h。使用光电子能谱(XPS)和碱量滴定法对炭黑表面官能团进行分析,结果表明硝酸氧化在炭黑表面引入了大量含氧官能团。激光粒度仪测定氧化炭黑混悬液的平均粒径为72nm,室温下放置180天后,平均粒径无变化。淋巴示踪实验表明,这种氧化炭黑制备的混悬液能在5m in内有效地黑染注射区域引流淋巴结,其染色效果优于商品卡纳琳的淋巴示踪剂。Carbon black （CB） was oxidized by concentrated nitric acid at 100 ℃ for 100 h to obtain a CB with excellent lymphatic tracing properties, which were characterized by XPS, alkalimetric titration and a staining test. It is found that nitric acid treatment obviously increases oxygen-containing functional groups on CB surface. The average diameter of the oxidized CB in suspension is 72 nm with no agglomeration found after storage at room temperature for 180 days. The suspension prepared with the oxidized CB can effectively color the injecting region of lymph nodes in 5 min. The staining effect is superior to a commercial available lymphatic tracer named Carbon Nanoparticle Suspension Injection.

关 键 词：氧化 炭黑 含氧官能团 淋巴示踪 

分 类 号：TQ421.7[化学工程]