硒与小儿肺炎关系的研究  

STUDIES ON THE RELATIONSHIP BETWEEN SELENIUM AND PNEUMONIA IN CHILDREN

作　　者：崔红[1] 荫士安[2] 高慧英[1] 李贵[1] 刘晓红[1] 孙素婉[1] 

机构地区：[1]北京市友谊医院儿科,100050 [2]中国预防医学科学院营养与食品卫生研究所

出　　处：《中华儿童保健杂志》1996年第4期196-199,共4页

摘　　要：为研究硒与小儿肺炎发生和发展的关系,测定了57例住院肺炎患儿和85例正常儿童的血浆、白细胞中硒和谷胱甘肽过氧化物酶(GSH-Px)活性以及尿中硒含量,建立了实验动物模型,以验证和补充说明临床所得结果。结果:肺炎患儿血浆和白细胞中硒含量及GSH-Px活性均有不同程度的降低;尿中硒含量有所增加。感染支原体肺炎后,富硒组大鼠间质性肺炎的罹患率较低;给低硒组灌喂亚硒酸钠后,病情轻且病程短。说明患儿在肺炎时体内硒的消耗增多;动物实验提示:良好的硒营养状态可降低肺炎的发生率;肺炎早期补充硒,可使肺炎病情减轻且病程缩短。In order to investigate the relationship between selenium(Se) status and pneumonia in children,the levels, of Se and glutathione peroxidase(GSH-Px) in plasma .white blood cells,and Se content in urine were measured in 57 cases with pneumonia and 85 control children under 10 years old. Animal experiment was done to try establish the model infected with pneumonia for verifying and adding the clinical results . Our results showed that the levels of Se and GSH-Px in plasma and white blood cell in the group of pneumonia were lower,but the content of Se in urine was higher. Se content and GSH-Px activity in white blood cells of patients during crisis were significantly lower than those of patients during convalescence. The present results indicate that expense of Se was increase during pneumonia in children. Animal experiment has proved that the morbidity of interstitial pneumonia in the group of feeding highter Se diet was lower after infected Mycoplasma Pneumoniae. The addition of sodium selenite might make interstitial pneumonia of Wistar mice abatement,course Curtailment.

关 键 词：肺炎 硒 儿童 

分 类 号：R725.631[医药卫生—儿科]