急性出血性白质脑病的临床病理研究  

Clinicalandmorphologicalfindingsinacutehemorrhagicleukoencephalopathy

作　　者：陈义林[1,2] 王鲁宁[1,2] 蒲传强[1,2] 吴霞丁 

机构地区：[1]华野解放军总医院神经内科 [2]北京军医总医院病理科

出　　处：《中华神经科杂志》1996年第6期344-346,共3页Chinese Journal of Neurology

摘　　要：为了探讨急性出血性白质脑病（ＡＨＬＥ）的临床病理特征，采用免疫组化染色的方法，对１例ＡＨＬＥ患者进行临床病理研究并复习我国以往报道的６例。结果显示，ＡＨＬＥ临床表现超急性特征，多数于短期内死亡；中枢神经病损部位为大脑（７／７）、脊髓（５／７，为全部经病检脊髓）、小脑（４／７）、脑干（４／７）；组化染色显示病灶内存有大量ＩｇＧ、ＩｇＡ、Ｃ３补体，并有Ｔ淋巴细胞浸润。结论：ＡＨＬＥ与免疫反应尤其是体液免疫密切相关；脊髓也是常见病损部位之一。Tostudytheclinicopathologicalcharacteristicsofacutehemorrhagicleukoencepha-lopathy(AHLE).AcomparativestudyontheclinicalandmorphologicalchangesinonecaseofAHLEencounteredinourhospitaland6casesofAHLEwhichwerereportedinChinapreviously.Itwasfoundthatashortincubationperiodandarapidlyprogressivecoursewithafatalterminationap-pearedtobethebasicclinicalcharacteristicsofAHLE.Theinvolvedareaswereinthebrains(7cases),inthespinalcords(5caseswithalthespinalcordswhichhadtheautopsydone),inthecerebela(4cases)andinthebrainstems(4cases).TheimmunohistochemicalstudyshowedthattherewereabundantdepositsofIgG,IgAandC3complementsinthenecrotizingareas.LymphocyticinfiltrationconsistedmainlyofTlymphocytes.AHLEwascorrelatedwiththeroleofhummoralim-munity.ThespinalcordwascommonlyinvolvedontheAHLEinChina.

关 键 词：急性 出血性白质脑病 脑炎 病理 

分 类 号：R512.302[医药卫生—内科学]