蛋白质去糖基化酶及其应用  

Deglycosylation enzyme of proteins and its application

作　　者：刘慧敏[1] 印大中[1] 

机构地区：[1]湖南师范大学生命科学学院,湖南长沙410081

出　　处：《现代生物医学进展》2006年第9期90-92,共3页Progress in Modern Biomedicine

摘　　要：果糖氨氧化酶和果糖氨激酶能催化去糖基化反应而释放出自由氨基。本文主要探讨阿马多里酶的生物化学特征。如结构和功能的关系,动力学机制和底物的特异性,并探讨这些酶的生物作用和在蛋白中去糖基化中的应用,希望为糖基化相关疾病的治疗提供很好的治疗手段。Fmctesyl lysine oxidase and fructose lysine 3 - phesphokinase can catalyze the deglycosylation reaction and generate free amino groups.This paper reviews the biochemical properties of these ＂amadoriase＂ enzymes, such as structural- function relationship, kinetic mechanism, and substrate specificity, as well as their biological roles and applications in the protein deglycosylation, which is expected to offer a promising therapeutic approch for the prevention and treatment of glycesylation related diseases.

关 键 词：去糖基化酶 阿马多里酶 衰老 

分 类 号：Q55[生物学—生物化学]