IRF-4结合蛋白——一个新的Th2极性分化相关分子  

IRF-4-binding protein: a new molecule associated with Th2 polarization

作　　者：周玉[1] 胡川闽[1] 

机构地区：[1]第三军医大学临床生化教研室,重庆400038

出　　处：《免疫学杂志》2006年第5期580-583,共4页Immunological Journal

基　　金：基金]国家自然科学基金资助项目(30471577)

摘　　要：Th细胞的极性分化在免疫反应调控中具有重要作用,Th细胞极化失调所致Th1/Th2失衡与多种疾病的发生相关。对于细胞因子、抗原信号,转录因子等影响Th1/Th2分化倾向的相关调控因素的研究已比较深入,但分化的具体分子机制尚未完全阐明。IRF-4结合蛋白(IBP)是一个新发现的与Th活化及Th2极性分化相关的分子,它的发现为Th极化的分子机制的研究提供了新的线索。本文就IBP的发现及其在Th细胞极化中的作用做一综述。The polarization of Th cells plays a critical role in regulation of immunological reaction. Imbalance of Th cell polarization counts for various diseases. The identification of parameters linked with Th1/Th2 commitment including cytokine stimulation, antigen recognition, and transcriptional activation has been intensively studied, but precise mechanisms of the Th cell polarization are still unclear. IRF-4 binding protein （IBP）, a new molecule which is associated with activation of Th and polarization of Th2 cells, provides a new clue for exploring molecular mechanisms of Th2 polarization.

关 键 词：IBP TH TH2 极性分化 

分 类 号：R392[医药卫生—免疫学]