羊胎盘提取液及其组分(SPIF-Ⅰ)的免疫活性研究  

Study on Immunoregulating Activity of Sheep Placental Extract and One of Its Component(SPIF-Ⅰ)

作　　者：吴开平[1] 陈丙波[1] 魏泓[1] 

机构地区：[1]第三军医大学基础部实验动物学教研室,重庆400038

出　　处：《氨基酸和生物资源》2006年第3期62-64,共3页Amino Acids & Biotic Resources

基　　金：国家自然科学资金(NO.30070120);重庆市2001年重点技术创新项目(147)资助

摘　　要：对羊胎盘提取液(Sheep p lacental extract,SPE)及其组分免疫调节活性因子-Ⅰ(Sheep p lacental immunoreglating ac-tivity factor-Ⅰ,SPIF-Ⅰ)进行高效液相色谱(HPLC)分析并通过E玫瑰花环试验进行免疫生物活性评价。结果表明:在羊胎盘提取液中质量分数为11.94%的SPIF-Ⅰ同羊胎盘提取液一样能显著促进人外周血淋巴细胞E玫瑰花环形成,具有明显的剂量-效应依赖关系。SPIF-Ⅰ是羊胎盘提取液中一种具有免疫调节的小分子活性多肽。The analysis of sheep placental extract and one of its component （ SPIF - I ） was made by reverse phase - high performance liquid chromatography （ RP - HPLC ）, and the appraisal of immunocompetence of them was measured by E - rosette test. The results showed that both sheep placental extract and SPIF - I could increase E - rosette formation of human munoreglating activity of sheep peripheral blood lymphocytes and that SPIF- I was a small chain peptide with implacenta extract.

关 键 词：羊胎盘 RP—HPLC 生物活性 

分 类 号：TQ460.7[化学工程—制药化工]