亚慢性苯染毒对大鼠脂质过氧化指标影响的实验研究  

An Experimental Study of Lipid Peroxidation of Subchronic Benzolism in Rats

作　　者：张强[1] 林立[1] 张凯[1] 曾晓立[1] 

机构地区：[1]济宁医学院职业卫生与环境医学研究所

出　　处：《济宁医学院学报》2006年第3期7-9,共3页Journal of Jining Medical University

摘　　要：目的探讨亚慢性苯染毒对大鼠脂质过氧化指标影响。方法在制备动物模型的基础上用化学比色法监测接苯大鼠血清中维生素E(VitE)、谷胱甘酞、丙二醛的含量及谷胱甘酞过氧化酶的活力,并进行常规白细胞计数。结果染毒组大鼠血清中白细胞数量、谷胱甘酞和VitE的下降,丙二醛、谷胱甘酞过氧化酶的升高存在剂量效应关系,各指标在高剂量组与对照组之间存在显著差异(P<0.05)。结论脂质过氧化指标VitE、谷胱甘酞、丙二醛含量的测定及谷胱甘酞过氧化酶活力的变化在苯中毒早期诊断中具有一定的意义。Objective In order to approach the lipid peroxidation of subchronic benzolism, we studied the change of the biological survilliance indeies in the serum of white rats poisoned by benzene. Methods Determining the indeies of lipid peroxidation（VitE ,MDA,GSH,GSH- Px） in the serum of white rat through 722 spectrometer and counting the white cells through optical microscope. Results The content of VitE, MDA, GSH and the activity of GSH-Px in the experimental tean are by far higher than white cell counting in the control team（P〈0.05）. Conclusion Monitoring the indeies of lipid peroxidation in the serun are valueable in early diagnosis to subchronic benzolism.

关 键 词：亚慢性苯中毒 脂质过氧化 大鼠 

分 类 号：R285.5[医药卫生—中药学]