MMP-9/TIMP-1在输卵管粘膜上皮中的表达及与输卵管妊娠关系的研究  

The Study on the Expression of mmp-9/timp-1 in Mucous Epithelium of Fallopian Tube and it's Relation to Tubal Pregnancy

作　　者：何萍[1] 钟玲[2] 

机构地区：[1]重庆市妇幼保健院,400010 [2]重庆医科大学第二附属医院

出　　处：《中国计划生育学杂志》2006年第9期543-545,共3页Chinese Journal of Family Planning

摘　　要：目的:检测基质金属蛋白酶-9(MMP-9)及其组织抑制物-1(TIMP-1)在输卵管粘膜上皮中的表达,探讨与输卵管妊娠的关系。方法:运用免疫组织化学染色结合病理图像半定量分析方法,检测12例正常输卵管壶腹部标本、12例输卵管炎标本、6例宫内早孕标本、16例输卵管壶腹部妊娠标本中MMP-9及TIMP-1的表达情况。结果:宫内早孕组与正常组比较、输卵管炎组与输卵管妊娠组比较差异均无显著意义(P>0·05);而输卵管炎组、宫内早孕组与正常组分别比较差异有显著意义(P<0·05),输卵管妊娠组、宫内早孕组和正常组比较差异也有显著意义(P<0·05)。结论:MMP-9/TIMP-1参与妊娠的生理过程,但妊娠在本实验中不是一个混杂因素;MMP-9/TIMP-1可能由于慢性炎症导致其表达失衡而参与输卵管妊娠的发生。Objective： To study the expression of MMP - 9/TIMP - 1 in fallopian tube and explore its possible mechanisms in tubal pregnancy. Methods： Ampulla of fallopian tube from 12 normal women, 6 early stage of intrauterine pregnancy woman, 12 patients with chronic salpingitis, and 16 tubal pregnancy were selected for our present study. Immunohistochemistry and semi - quantity pathologic image software system were used to analyze the expression of MMP - 9/TIMP - 1 respectively in a- bove - mentioned mucous epithelium of fallopian tube. Results： No significant difference was found in both for MMP - 9/TIMP - 1 expression between the normal group and women with early intrauterine pregnancy （ P 〉 0. 05 ） ; no significant difference was found in both for MMP - 9/TIMP - 1 expression between tubal pregnancy and salpingitis （ P 〈 0. 05 ） ; significant difference was found in both for MMP -9/TIMP - 1 expression between salpingitis and normal tube and early intrauterine pregnancy （P 〉 0. 05 ） ; Significant difference was found in both for MMP -9/TIMP - 1 expression between tubal pregnancy and normal tube and early intrauterine pregnancy（P 〈0. 05）. Conclusion： （1） MMP -9/TIMP -1 take part in physiological process of normal pregnancy, but pregnancy itself is not a miscellaneous factor in our study. （2） Imbalanced - expression of MMP - 9/ TIMP - 1 probably participated in the formation of tubal pregnancy through chronic inflammation of fallopian tube.

关 键 词：基质金属蛋白酶-9 基质金属蛋白酶的组织抑制物-1 输卵管炎 输卵管妊娠 

分 类 号：R714.22[医药卫生—妇产科学]