新型吡啶类鬼臼毒素衍生物对淡色库蚊的生物活性研究  

Insecticidal Activity of Twelve Novel Pyridine Ring Derivatives of Podophyllotoxin

作　　者：刘艳青[1] 张守刚[1] 程洁[1] 肖杭[1] 高蓉[1] 

机构地区：[1]南京医科大学应用毒理研究所神经毒理室,南京210029

出　　处：《实验动物与比较医学》2006年第3期144-147,共4页Laboratory Animal and Comparative Medicine

基　　金：国家自然科学基金资助项目(批准号:30371169)

摘　　要：目的研究新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的的毒杀活性。方法采用WHO生物测试法测定吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀活性。结果12种新型吡啶类鬼臼毒素衍生物对3龄淡色库蚊幼虫的毒杀作用有明显的差异,化合物4.4、4.5和4.6的毒杀作用明显高于其它化合物。结论12种新型吡啶类鬼臼毒素衍生物对3龄初淡色库蚊幼虫毒杀作用的差异可能与结构上的差异有关。Objective The bioactivity of twelve novel pyridine ring derivatives of podophyllotoxin were tested against 3rd instar larvae of Culex pipiens pallens. Methods Using WHO bioassay method. Results From twelve novel pyridine ring derivatives ofpodophyllotoxin, three compounds 4.4, 4.5 and 4.6 have more higher toxicities than others, and the LC50 were 1.66, 3.96 and 1.54 mg/L respectively. Conclusion Based on the data obtained in this investigation, it is possible that the dissimilarity in the structure of the analogues leads to their different bioactivity.

关 键 词：吡啶类鬼臼毒素 淡色库蚊 植物源杀虫剂 

分 类 号：R96[医药卫生—药理学]